No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course
| Autor: | Bolette Hartmann, Jens J. Holst, Tina Vilsbøll, Kristian Hallundbæk Mikkelsen, Morten Frost, Filip K. Knop |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Peptides/blood medicine.drug_class Collagen Type I/blood Endocrinology Diabetes and Metabolism Antibiotics Osteocalcin 030209 endocrinology & metabolism Gut flora lcsh:Diseases of the endocrine glands. Clinical endocrinology Serotonin secretion Collagen Type I Bone remodeling Anti-Bacterial Agents/pharmacology 03 medical and health sciences 0302 clinical medicine Sex hormone-binding globulin Osteogenesis Internal medicine medicine Humans Gastrointestinal Microbiome/drug effects lcsh:RC648-665 biology business.industry Glucagon-Like Peptide-2 Receptor/blood Osteocalcin/blood General Medicine biology.organism_classification Anti-Bacterial Agents Gastrointestinal Microbiome Osteogenesis/drug effects 030104 developmental biology Endocrinology Bone Remodeling/drug effects biology.protein Glucagon-Like Peptide-2 Receptor Anaerobic bacteria Bone Remodeling business Peptides Biomarkers Biomarkers/blood Hormone Research Article |
| Zdroj: | Mikkelsen, K H, Vilsbøll, T, Holst, J J, Hartmann, B, Knop, F K & Frost, M 2018, ' No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course ', BMC Endocrine Disorders, vol. 18, 60 . https://doi.org/10.1186/s12902-018-0291-x BASE-Bielefeld Academic Search Engine Mikkelsen, K H, Vilsboll, T, Holst, J J, Hartmann, B, Knop, F K & Frost, M 2018, ' No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course ', BMC Endocrine Disorders, vol. 18, 60 . https://doi.org/10.1186/s12902-018-0291-x BMC Endocrine Disorders BMC Endocrine Disorders, Vol 18, Iss 1, Pp 1-6 (2018) |
| DOI: | 10.1186/s12902-018-0291-x |
| Popis: | Background: Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects may be mediated by changes in sex hormone biotransformation in the gut, gut serotonin secretion or nutrition-induced secretion of glucagon-like peptide 2 (GLP-2) and glucose-dependent insulinotropic hormone (GIP). Antibiotics change the human gut microbiota, but the effect of antibiotic treatment on human bone turnover is unknown. Methods: We analyzed serum levels of bone turnover markers, serotonin, GLP-2 and sex hormones before, immediately after, and eight, 42 and 180 days after a 4-day per oral antibiotic cocktail (vancomycin 500 mg, gentamycin 40 mg and meropenem 500 mg once-daily) in twelve healthy adult males. Fasting and meal-stimulated procollagen type I amino-terminal propeptide (P1NP), C-telopeptide of type I collagen (CTX) and osteocalcin levels were measured. Results: While the antibiotic course reduced the stool abundance and composition of anaerobic bacteria as confirmed by cultivation studies, neither short nor long-term alterations in serum P1NP, CTX and osteocalcin were observed. Furthermore, we did not observe any changes in levels of serum GLP-2, serotonin or sex hormones. Conclusion: Eradication of anaerobic bacteria from healthy adult males had no effect on serum bone turnover markers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|