Significance of p16 Positive Expression in Oropharyngeal Cancers
| Autor: | Juliana Lucena Schussel, Regiane Benez Bixofis, Laurindo Moacir Sassi, Sérgio Ossamu Ioshii, Cleverson Patussi, Juliana E Jung |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology Larynx Cancer Research medicine.medical_specialty Alcohol Drinking Epidemiology Disease medicine.disease_cause Internal medicine medicine Carcinoma Humans Stage (cooking) Cyclin-Dependent Kinase Inhibitor p16 Aged Squamous Cell Carcinoma of Head and Neck business.industry Papillomavirus Infections Smoking Public Health Environmental and Occupational Health HPV infection Cancer Middle Aged medicine.disease Immunohistochemistry Neoplasm Proteins Oropharyngeal Neoplasms medicine.anatomical_structure Head and Neck Neoplasms Carcinoma Squamous Cell Female Carcinogenesis business Brazil |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 15:10289-10292 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2014.15.23.10289 |
| Popis: | Background: The involvement of HPV in oral and oropharyngeal carcinogenesis was first proposed in 2004, based on epithelial HPV tropism and detection of HPV genotypes in oral squamous cell carcinoma samples. While 60-70% of oropharynx tumors may be HPV-positive, only 10 to 19% of tumors of the oral cavity, larynx and hypopharynx appear to have HPV infection. The aim of the study was to evaluate HPV infection associated with oropharyngeal cancer. Materials and Methods: Seventy-eight cases were selected for p16 immunoexpression reactions, and demographic data were collected for comparisons. Results: Most patients were over 60 years old, and 64.1% were smokers. Immunohistochemistry results showed that 86.3% of cases stained positive for p16 protein. Conclusion: The oropharyngeal cancer profile at Erasto Gaertner Hospital presented a high index of smokers over 60 years as well a high number of p16+ tumors, for what we can not determinate the main etiologic factor, but can be aware of the number of patients that presented HPV infection. Since prevention is still the best way to deal with cancer disease, it is important to analyze the interaction of these two etiologic factors and how to detect lesions at an early stage. |
| Databáze: | OpenAIRE |
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