Increased volume of gastric contents in diabetic patients undergoing renal transplantation: lack of effect with cisapride
| Autor: | R. Orko, Leena Lindgren, Marja-Riitta Taskinen, E. Reissell |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Administration Oral Anesthesia General Placebo Placebos Double-Blind Method Piperidines Diabetes mellitus medicine Humans Gastroparesis Defecation Uremia Cisapride Gastric emptying business.industry Stomach Gastric Acidity Determination General Medicine Hydrogen-Ion Concentration medicine.disease Kidney Transplantation Gastrointestinal Contents Transplantation Diabetes Mellitus Type 1 Anesthesiology and Pain Medicine medicine.anatomical_structure Gastric Emptying Anesthesia Serotonin Antagonists Gastrointestinal Motility Complication business medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 36:736-740 |
| ISSN: | 1399-6576 0001-5172 |
| Popis: | Gastroparesis is a frequently unrecognized complication of insulin-dependent diabetes mellitus, which subjects these patients to the risk of aspiration at induction of anaesthesia. The effect of oral cisapride on volume and pH of gastric contents was studied in 24 diabetic and 24 non-diabetic uraemic patients undergoing renal transplantation. All patients were allocated randomly in a double-blind fashion to receive either 10 mg of cisapride or placebo orally approximately 100 min before anaesthesia and three times daily for the first 2 postoperative days. After the induction of anaesthesia, gastric contents were aspirated through a nasogastric tube, and the pH and volume were measured. The emptiness of the stomach was verified by gastroscopy. Gastric volumes exceeding 0.4 ml · kg-1 were observed in 12/24 of the diabetic and 4/24 of the non-diabetic uraemic patients (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text