Rutaecarpine attenuates osteoclastogenesis by impairing macrophage colony stimulating factor and receptor activator of nuclear factor κ-B ligand-stimulated signalling pathways
| Autor: | Eiko Sakai, Yutaka Fukuma, Kuniaki Okamoto, Kazuhisa Nishishita, Shunsuke Komaki, Takayuki Tsukuba |
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| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
Macrophage colony-stimulating factor Physiology Osteoclasts 01 natural sciences Bone resorption Indole Alkaloids Osteoclast Osteogenesis Physiology (medical) medicine Animals Bone Resorption Receptor Cells Cultured Pharmacology biology Dose-Response Relationship Drug 010405 organic chemistry Chemistry Activator (genetics) Macrophage Colony-Stimulating Factor Macrophages RANK Ligand Cell Differentiation Rutaecarpine 0104 chemical sciences Cell biology 010404 medicinal & biomolecular chemistry medicine.anatomical_structure RANKL biology.protein Quinazolines Phosphorylation Signal Transduction |
| Zdroj: | Clinical and experimental pharmacologyphysiology. 45(8) |
| ISSN: | 1440-1681 |
| Popis: | Rutaecarpine is a major alkaloid isolated from Evodia rutaecarpa. Here, we investigated the effects of rutaecarpine on osteoclast differentiation induced by macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor κ-B ligand (RANKL) in bone marrow-derived macrophages (BMMs). Treatment with rutaecarpine significantly inhibited osteoclastogenesis and prevented bone resorption of BMM-derived osteoclasts. Mechanistically, rutaecarpine decreased the protein level of nuclear factor of activated T cells cytoplasmic-1 (NFATc1) and the phosphorylation of other signalling pathways during the osteoclast differentiation. Thus, rutaecarpine may be useful as a therapeutic agent for the treatment of bone diseases. |
| Databáze: | OpenAIRE |
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