Alterations in the rap1 signaling pathway are common in human gliomas
| Autor: | Susan Saporito-Irwin, Ralf Wienecke, David H. Gutmann, Jeffrey E. DeClue, Abhijit Guha |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
endocrine system Cancer Research Tumor suppressor gene Blotting Western Biology Central nervous system disease Tuberous sclerosis GTP-Binding Proteins Proto-Oncogene Proteins Glioma Tuberous Sclerosis Complex 2 Protein Genetics medicine Humans Genes Tumor Suppressor neoplasms Molecular Biology Brain Neoplasms Tumor Suppressor Proteins Cyclin-Dependent Kinase 4 Cancer medicine.disease Cyclin-Dependent Kinases Oligodendrocyte nervous system diseases Repressor Proteins enzymes and coenzymes (carbohydrates) rap GTP-Binding Proteins medicine.anatomical_structure Immunology Cancer research TSC2 Signal transduction Meningioma Neurilemmoma |
| Zdroj: | Oncogene. 15:1611-1616 |
| ISSN: | 1476-5594 0950-9232 |
| Popis: | Several inherited predisposition to cancer syndromes are associated with the development of nervous system tumors. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder in which affected individuals are at risk for developing astrocytomas. One of the genes responsible for this disorder is TSC2, located on chromosome 16p, and encoding a 180 kDa protein (tuberin) that functions in part as a negative regulator of rap1. Previous studies from our laboratory demonstrated that 30% of sporadic astrocytomas have reduced or absent tuberin expression. In addition to loss of tuberin in sporadic astrocytomas, aberrant rap1 mediated signaling may also result from overexpression of rap1. In this study, we test the hypothesis that alterations in the rap1 signaling pathway are frequently observed in certain subsets of gliomas compared to other tumors of the nervous system. Analysis of sporadic astrocytomas and ependymomas demonstrated either increased rap1 or reduced/absent tuberin protein expression in 50 – 60% of different cohorts of these gliomas, compared to 30 – 33% of sporadic schwannomas and meningiomas and none of eight oligodendrocyte tumors. These results suggest that alterations in the rap1 signaling pathway are important in the development of certain sporadic human gliomas. |
| Databáze: | OpenAIRE |
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