Antinociceptive and Anti-Inflammatory Activities of the Sesame Oil and Sesamin
| Autor: | Érika Maria Henriques Monteiro, Orlando Vieira de Sousa, Ana Lúcia Santos de Matos Araújo, Mirian Pereira Rodarte, Mônica Cecília Santana Pereira, Célia Hitomi Yamamoto, Aílson da Luz André de Araújo, Maria da Penha Henriques do Amaral, Marcelo Silva Silvério, Miriam Aparecida de Oliveira Pinto, Glauciemar Del-Vechio-Vieira, Fernanda Maria Pinto Vilela, Lucas A. Chibli |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Nociception medicine.drug_class Anti-Inflammatory Agents Pain lcsh:TX341-641 Dioxoles Carrageenan Anti-inflammatory Article Lignans sesame oil chemistry.chemical_compound Mice sesamin Sesamin Formaldehyde medicine Toxicity Tests Acute Animals Edema Food science Hot plate Rats Wistar anti-inflammatory activity Pleurisy Acetic Acid Inflammation Analgesics Nutrition and Dietetics antinociceptive activity Rats chemistry Biochemistry Sesame oil lcsh:Nutrition. Foods and food supply Leucocyte migration Food Science Paw edema |
| Zdroj: | Nutrients, Vol 6, Iss 5, Pp 1931-1944 (2014) Nutrients Nutrients; Volume 6; Issue 5; Pages: 1931-1944 |
| ISSN: | 2072-6643 |
| Popis: | Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product. |
| Databáze: | OpenAIRE |
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