Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma
| Autor: | Golfieri, R., Giampalma, E., Renzulli, M, Cioni, R., Bargellini, I., Bartolozzi, C., Breatta, A. D., Gandini, G., Nani, R., Gasparini, D., Cucchetti, A., Bolondi, L., Trevisani, COLLABORATORS:Mosconi C, F., Cappelli, A, Galaverni, Mc, Pini, P, Piscaglia, F, Benevento, F, Giampaolo, L, Caprara, C, Menichella, R, Lenzi, M, Bernardi, M, Santi, V, Erroi, V, Mazzella, G, Colecchia, A, Montrone, L, Schiumerini, R, Bianchi, G, Zoli, M, Martini, G, Fraticelli, L, Sama, C, Berardi, S, Serra, C, Vignali, C, Bianchi, F, Vallini, V, Carrai, P, Filipponi, F, Moneta, S, Pea, E, Giunta, S, Sacco, R, Ricchiuti, A, di Fluri, G, Coco, B, Rossato, D, Vighetti, C, Battisti, G, Rapellino, A, Carucci, P, Cosso, L, Rizzetto, M, Mirabella, S, Sturniolo, L, Catalano, Giorgia, Salizzoni, M, Agazzi, R, Limonta, S, Fagiuoli, S, Verga, G, Magini, G, Aprile, G, Vit, A. |
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| Přispěvatelé: | Golfieri, R, Giampalma, E, Renzulli, M, Cioni, R, Bargellini, I, Bartolozzi, C, Breatta, A, Gandini, G, Nani, R, Gasparini, D, Cucchetti, A, Bolondi, L, Trevisani, F, Fagiuoli, S, Golfieri, Rita, Giampalma, Emanuela, Renzulli, Matteo, Cioni, R., Bargellini, I., Bartolozzi, Catia, Breatta, A. D., Gandini, Gualtiero, Nani, R., Gasparini, D., Cucchetti, Alessandro, Bolondi, Luigi, Trevisani, Franco, on behalf of the PRECISION ITALIA STUDY GROUP:, [. . ., Piscaglia, Fabio, Bernardi, Mauro, IBARRA GASPARINI, Daniela, ], . . |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Abdominal pain Cancer Research Carcinoma Hepatocellular intra-arterial hepatic therapy mRECIST Gastroenterology survival law.invention liver cancer Randomized controlled trial law Antibiotics Internal medicine medicine Carcinoma Humans Prospective Studies HEPATOCELLULAR CARCINOMA Chemoembolization Therapeutic Adverse effect Prospective cohort study Survival rate Aged Antibiotics Antineoplastic business.industry Liver Neoplasms Hepatocellular medicine.disease Doxorubicin Female Survival Rate Oncology Antineoplastic Surgery Hepatocellular carcinoma Clinical Study Chemoembolization medicine.symptom Therapeutic Liver cancer business |
| Zdroj: | British Journal of Cancer |
| Popis: | Background: Transcatheter arterial chemoembolisation (TACE) is the treatment of choice for intermediate stage hepatocellular carcinoma (HCC). Doxorubicin-loaded drug-eluting beads (DEB)-TACE is expected to improve the performance of conventional TACE (cTACE). The aim of this study was to compare DEB-TACE with cTACE in terms of time-to-tumour progression (TTP), adverse events (AEs), and 2-year survival. Methods: Patients were randomised one-to-one to undergo cTACE or DEB-TACE and followed-up for at least 2 years or until death. Transcatheter arterial chemoembolisation was repeated ‘on-demand'. Results: We enrolled 177 patients: 89 underwent DEB-TACE and 88 cTACE. The median number of procedures was 2 in each arm, and the in-hospital stay was 3 and 4 days, respectively (P=0.323). No differences were found in local and overall tumour response. The median TTP was 9 months in both arms. The AE incidence and severity did not differ between the arms, except for post-procedural pain, more frequent and severe after cTACE (P |
| Databáze: | OpenAIRE |
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