Increased plasma brain natriuretic peptide levels in DOCA-salt hypertensive rats: Relation to blood pressure and cardiac concentration
| Autor: | Naoto Yokota, Kenjiro Tanaka, Yamamoto Y, Hisayuki Matsuo, Tanenao Eto, Kenji Kangawa, Osamu Kida, Kazuo Kitamura, Johji Kato, Masahito Aburaya, Naoto Minamino |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Heart Ventricles Biophysics Nerve Tissue Proteins Peptide hormone Doca salt Biochemistry Atrial natriuretic peptide Internal medicine Natriuretic Peptide Brain Blood plasma medicine Animals Heart Atria cardiovascular diseases Desoxycorticosterone Molecular Biology Hypertensive group Chemistry Rats Inbred Strains Radioimmunoassay Cell Biology Brain natriuretic peptide Rats Endocrinology Blood pressure Immunoglobulin G Hypertension Chromatography Gel cardiovascular system human activities Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Biochemical and Biophysical Research Communications. 173:632-638 |
| ISSN: | 0006-291X |
| Popis: | Four experimental groups of rats treated with (1) DOCA-salt, (2) DOCA or (3) salt, and (4) controls were used to study the participation of brain natriuretic peptide (BNP) in the development of hypertension. Plasma and cardiac tissue concentrations of BNP as well as atrial natriuretic peptide (ANP) were measured in each group by using radioimmunoassays specific to rat BNP or ANP. Plasma BNP levels in DOCA-salt hypertensive group were higher than those in control (p less than 0.01), salt (p less than 0.01) and DOCA (p less than 0.01) groups. A positive correlation was observed between plasma BNP levels and blood pressure (r = 0.70, p less than 0.001) and between plasma ANP levels and blood pressure (r = 0.62, p less than 0.001). Plasma BNP/ANP ratio increased parallel with elevation of blood pressure. Plasma BNP levels correlated negatively with atrial BNP concentration (r = -0.33, p less than 0.05), but positively with ventricular BNP (r = 0.76, p less than 0.001). Compared with controls, tissue BNP-45/gamma-BNP ratio in the DOCA-salt rats was lower in atrium, but higher in ventricle. Thus, in DOCA-salt hypertension atrial BNP decreased with exhaustion of stored BNP-45, while ventricular BNP increased as BNP-45 accumulated. These results suggest that BNP is a novel cardiac hormone, synthesized, processed and secreted in response to changes in blood pressure. BNP may play different roles in controlling blood pressure than those assumed by ANP. |
| Databáze: | OpenAIRE |
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