The Role of Lysophosphatidic Acid Receptors in Ovarian Cancer: A Minireview
| Autor: | Huimin Bai, Ran Cui, Zhenyu Zhang, Guangming Cao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Vascular Endothelial Growth Factor A
Chemokine CXCL1 AMP-Activated Protein Kinases medicine.disease_cause chemistry.chemical_compound Lysophosphatidic acid Genetics medicine Humans Cyclin D1 Receptors Lysophosphatidic Acid Receptor Molecular Biology G protein-coupled receptor Ovarian Neoplasms LPAR1 Interleukins LPAR6 medicine.disease Urokinase-Type Plasminogen Activator Peptide Fragments Gene Expression Regulation Neoplastic Cytoskeletal Proteins Cell Transformation Neoplastic chemistry Cyclooxygenase 2 Disease Progression Cancer research Female lipids (amino acids peptides and proteins) Lysophospholipids Carcinogenesis Ovarian cancer Function (biology) Signal Transduction |
| Zdroj: | Critical Reviews in Eukaryotic Gene Expression. 30:265-272 |
| ISSN: | 1045-4403 |
| Popis: | Lysophosphatidic acid (LPA) is a bioactive lipid component of ovarian cancer activating factor, which is present at a high concentration in the ascitic fluid and plasma of patients with ovarian cancer. A group of six lysophosphatidic acid receptors (LPARs), LPAR1 through LPAR6, which belong to the G protein-coupled receptor superfamily (GPCR), mediate cellular activities of LPA and activates a series of downstream molecules and cellular responses, including biological and pathological effects. LPARs are widely expressed in normal ovary, benign tumor, and ovarian cancer tissues and cancer cell lines with a broad range of levels. The LPA/LPAR axis is involved in tumorigenesis and development of ovarian cancer through mediating the cellular responses to LPA and influencing the expression and function of oncogenic molecules. In the present review, the roles of LPARs in ovarian cancer, including the expression, function, and downstream molecules, are summarized, and we discuss the implications for ovarian cancer treatment that targets LPARs. |
| Databáze: | OpenAIRE |
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