Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy
| Autor: | Thomas A. Premeaux, Shireen Javandel, Kalei R. J. Hosaka, Meredith Greene, Nicholas Therrien, Isabel E. Allen, Michael J. Corley, Victor G. Valcour, Lishomwa C. Ndhlovu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Aging Cross-sectional study morbidity HIV Infections Cohort Studies chemistry.chemical_compound 0302 clinical medicine Medicine Immunology and Allergy Viral Original Research Veterans education.field_of_study biology Neopterin Middle Aged Infectious Diseases Anti-Retroviral Agents Medical Microbiology HIV/AIDS Cytokines RNA Viral Female Cystatin Inflammation Mediators Infection Cohort study lcsh:Immunologic diseases. Allergy Galectins Population Immunology Renal function Fibrin Fibrinogen Degradation Products 03 medical and health sciences Clinical Research Humans Cystatin C education Aged business.industry Inflammatory and immune system HIV Membrane Proteins anti-retroviral therapy medicine.disease Comorbidity 030104 developmental biology chemistry inflammation biology.protein RNA business lcsh:RC581-607 Biomarkers 030215 immunology |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
| ISSN: | 1664-3224 |
| Popis: | The prevalence of age-related comorbidities is increased in people living with HIV, even in those well-controlled on combination antiretroviral therapy (ART). Persistent immune activation and inflammation may play pivotal roles in the pathogenesis; however, the burden of morbidities in the older HIV infected population may be exacerbated and driven by distinct mechanisms. In a cross sectional study of 45 HIV-infected participants 60 years or older, we examined the relationships between 14 immunomodulatory and inflammatory factors and the Veterans Aging Cohort Study (VACS) Index, a metric of multimorbidity and mortality comprised of age, CD4 count, hemoglobin, Fibrosis-4 [FIB-4], and estimated glomerular filtration rate [eGFR], by linear regression analysis. All participants were virally suppressed ( |
| Databáze: | OpenAIRE |
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