Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor

Autor:	Alexey Stepanov, S. M. Deev, A. S. Rybinets, M. A. Dronina
Rok vydání:	2016
Předmět:	STAT3 Transcription Factor 0301 basic medicine Interleukin-17 receptor digestive system General Biochemistry Genetics and Molecular Biology Stat3 Signaling Pathway 03 medical and health sciences Interleukin-4 receptor Cytokine Receptor gp130 Enzyme-linked receptor Humans Chemistry digestive oral and skin physiology General Medicine Glycoprotein 130 biological factors Fibronectins Cell biology HEK293 Cells 030104 developmental biology Interleukin-21 receptor cardiovascular system Protein Multimerization biological phenomena cell phenomena and immunity Signal transduction Interleukin 1 receptor type I Signal Transduction
Zdroj:	Bulletin of Experimental Biology and Medicine. 161:72-74
ISSN:	1573-8221 0007-4888
DOI:	10.1007/s10517-016-3348-8
Popis:	Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings can be used as the basis in designing novel therapeutic gp130 inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d296dacf0e957fd82112f8a3977eecf https://doi.org/10.1007/s10517-016-3348-8 Zobrazit plný text záznamu Full text from SpringerLink