Retinal Pigment Epithelium Differentiation of Stem Cells: Current Status and Challenges
| Autor: | Basak E. Uygun, Martin L. Yarmush, Nripen Sharma |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Retinal pigment epithelium
Gene therapy of the human retina Guided Tissue Regeneration Retinal Detachment Biomedical Engineering Anatomy Biology medicine.disease Embryonic stem cell Article eye diseases Cell biology Transplantation medicine.anatomical_structure Retinitis pigmentosa medicine Animals Humans sense organs Stem cell Induced pluripotent stem cell Forecasting Stem Cell Transplantation Retinal regeneration |
| Zdroj: | Critical Reviews™ in Biomedical Engineering. 37:355-375 |
| ISSN: | 0278-940X |
| DOI: | 10.1615/critrevbiomedeng.v37.i4-5.30 |
| Popis: | Degeneration and loss of retinal pigment epithelium (RPE) is the cause of a number of degenerative retinal diseases, including age-related macular degeneration (AMD), retinitis pigmentosa, and diabetic retinopathy, leading to blindness that affects three million Americans as of now. Transplantation of RPE aims to restore retinal structure and the interaction between the RPE and photoreceptors, which is fundamental to sight. Although a significant amount of progress has been made in the past 20 years in autologous RPE transplantation, sources for RPE cells are limited. Recent advances in stem cell culture and differentiation techniques have allowed the generation of RPE cells from pluripotent stem cells. In this review, we discuss strategies for generating functional RPE cells from human embryonic stem cells and induced pluripotent stem cells, and summarize transplantation studies of these derived RPEs. We conclude with challenges in cell-replacement therapies using human embryonic and induced pluripotent stem cell-derived RPEs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|