Effect on quality of life of switching to combined oral contraception based on natural estrogen: an observational, multicentre, prospective phase IV study (ZOCAL Study)
| Autor: | Rafael Sánchez-Borrego, Esther de la Viuda, Rainel Sánchez-de la Rosa, Ezequiel Pérez-Campos, María Ángeles Gómez Martínez, Jesus Novalbos, Iñaki Lete |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Metrorrhagia Adolescent Population Ethinyl Estradiol Condoms Premenstrual Syndrome 03 medical and health sciences Young Adult 0302 clinical medicine Patient satisfaction Quality of life Ethinylestradiol medicine Humans Nandrolone Pharmacology (medical) 030212 general & internal medicine Prospective Studies education Prospective cohort study Gynecology education.field_of_study 030219 obstetrics & reproductive medicine Obstetrics business.industry Obstetrics and Gynecology Megestrol Middle Aged Contraceptives Oral Combined Reproductive Medicine Family planning Patient Satisfaction Quality of Life Observational study Female medicine.symptom business medicine.drug |
| Zdroj: | The European journal of contraceptionreproductive health care : the official journal of the European Society of Contraception. 21(4) |
| ISSN: | 1473-0782 |
| Popis: | Objectives: This observational, multicentre, prospective phase IV study examined change in health-related quality of life (QOL) from baseline to 6 months in women initiating combined oral contraception (COC) based on natural estrogen. Methods: Eligible women attending a baseline and 6-month gynaecology appointment belonged to one of three groups: group 1 used barrier contraception (condoms) and elected to continue this method; group 2 used condoms and elected to switch to COC based on natural estrogen; group 3 used COC based on ethinylestradiol and elected to switch to COC based on natural estrogen. The Spanish Society of Contraception (SEC)-QOL scale assessed health-related QOL. Secondary outcomes included symptoms of premenstrual syndrome, intermenstrual bleeding, duration and intensity of menstrual bleeding, contraception continuation rate, and tolerability. Results: A total of 857 women were enrolled and 785 completed the study. Group 2 (n = 224 completed) had significantly lower SEC-QOL global and dimension scores at baseline and significantly greater increases in SEC-QOL from baseline to 6 months compared with groups 1 (n = 72) and 3 (n = 489). Group 3 reported a similar SEC-QOL score to that of group 1 at baseline but showed significantly greater improvement in SEC-QOL global and psychological scores from baseline to 6 months. Among women receiving COC based on natural estrogen, the contraception continuation rate was 713/780 (91.4%); treatment-related adverse events were reported by 13/780 (1.7%). Conclusions: Improved SEC-QOL after 6 months was found in women who were dissatisfied with their current contraception at baseline and chose to switch to COC based on natural estrogen. |
| Databáze: | OpenAIRE |
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