Modulation of Immune Reactivity by Phenylimidothiazole Salts in Mice Immunized by Sheep Red Blood Cells

Autor:	G, Renoux, M, Renoux
Rok vydání:	1974
Předmět:	Erythrocytes Sheep Time Factors Dose-Response Relationship Drug Immunology Tetramisole Hemolytic Plaque Technique Organ Size Mice Levamisole Antibody Formation Animals Immunology and Allergy Female Antigens Antibody-Producing Cells Spleen
Zdroj:	The Journal of Immunology. 113:779-790
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.113.3.779
Popis:	Two phenylimidothiazole salts, racemic tetramisole and l-isomer, levamisole, modulate mouse immune responsiveness. They produce either enhancement or depression of the number of plaque-forming cells (PFC) to sheep red blood cells (SRBC), depending on the dose and on time of administration of the drugs in relation to antigenic stimulus. They can render antigenic a quantity of SRBC which was insufficient in itself to immunize mice. These effects are not accompanied with an increase of serum antibody level. Immunostimulation does not modify the horse red cell background response. Enhanced immune responses are associated to splenocontraction, whereas the number of nucleated cells per spleen remains unchanged. Steric configuration of phenylimidothiazole salts plays a role, in that the d-optic isomer is almost completely devoid of immuno-modifying activities. The possible relationships between immunologic and pharmacologic activities of phenylimidothiazole salts are discussed.
Databáze:	OpenAIRE
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