A photothermal-hypoxia sequentially activatable phase-change nanoagent for mitochondria-targeting tumor synergistic therapy
| Autor: | Yang Wang, Shihui Guan, Zhigang Wang, Dengke Teng, Guoqing Sui, Jia Qu, Qimeihui Wang, Hui Wang, Yuanqiang Lin, Haitao Ran |
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| Rok vydání: | 2020 |
| Předmět: |
Indoles
Cell Survival medicine.medical_treatment Cell Biomedical Engineering Antineoplastic Agents Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Photoacoustic Techniques chemistry.chemical_compound In vivo Cell Line Tumor Neoplasms medicine Animals Prodrugs General Materials Science Photosensitizer Mice Inbred BALB C Photosensitizing Agents Chemistry Lasers Optical Imaging Photothermal therapy Prodrug 021001 nanoscience & nanotechnology Cell Hypoxia 0104 chemical sciences Drug Liberation medicine.anatomical_structure Photochemotherapy Biophysics Nanoparticles Female Tirapazamine Reactive Oxygen Species 0210 nano-technology Intracellular |
| Zdroj: | Biomaterials Science. 8:3116-3129 |
| ISSN: | 2047-4849 2047-4830 |
| DOI: | 10.1039/d0bm00003e |
| Popis: | To enhance the specificity and efficiency of anti-tumor therapies, we have designed a multifunctional nanoparticle platform for photochemotherapy using fluorescence (FL) and photoacoustic (PA) imaging guidance. Nanoparticles (NPs) composed of a eutectic mixture of natural fatty acids that undergo a solid-liquid phase transition at 39 °C were used to encapsulate materials for the rapid and uniform release of the hypoxia-activated prodrug tirapazamine (TPZ) and the photosensitizer IR780, which targets the mitochondria of tumor cells and can be used to induce hypoxic cell death via photodynamic therapy and photothermal therapy. In vitro, the NPs containing TPZ and IR7890 exhibited appreciable cell uptake and triggered drug release when irradiated with a NIR laser. In vivo, photochemotherapy of the NPs achieved the best anti-tumor efficacy under PA and FL imaging guidance and monitoring. By combining IR780 mitochondria-targeting phototherapy with TPZ, we observed improved anti-tumor effectiveness and this has the potential to reduce the side effects of traditional chemotherapy. Herein, we demonstrate a new intracellular photochemotherapy nanosystem that co-encapsulates photosensitizers and hypoxia-activated drugs to enhance the overall anti-tumor effect precisely and efficiently. |
| Databáze: | OpenAIRE |
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