Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: A possible role for lithium antioxidant effects
| Autor: | Valentim Gentil, Luiz Valmor Portela, Rodrigo Machado-Vieira, Victor Hermes Cereser, Carlos Ivan Viale, Ana Cristina Andreazza, Mirian Salvador, Diogo O. Souza, Vanessa Cassina Zanatto, Flávio Kapczinski, Rafael da Silva Vargas |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Antioxidant Lithium (medication) Thiobarbituric acid medicine.medical_treatment medicine.disease_cause Thiobarbituric Acid Reactive Substances Superoxide dismutase chemistry.chemical_compound Internal medicine mental disorders medicine TBARS Humans Bipolar disorder Analysis of Variance biology Superoxide Dismutase business.industry General Neuroscience Catalase medicine.disease Oxidative Stress Neuroprotective Agents Endocrinology chemistry Case-Control Studies Phosphopyruvate Hydratase biology.protein Female medicine.symptom Lithium Chloride business Mania Oxidative stress medicine.drug |
| Zdroj: | Neuroscience Letters. 421:33-36 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2007.05.016 |
| Popis: | Studies have proposed the involvement of oxidative stress and neuronal energy dysfunctions in the pathophysiology of bipolar disorder (BD). This study evaluates plasma levels of the oxidative/energy metabolism markers, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and neuron-specific enolase (NSE) during initial episodes of mania compared to controls in 75 subjects. Two groups of manic subjects (unmedicated n=30, and lithium-treated n=15) were age/gender matched with healthy controls (n=30). TBARS and antioxidant enzymes activity (SOD and CAT) were increased in unmedicated manic patients compared to controls. Conversely, plasma NSE levels were lower during mania than in the controls. In contrast, acute treatment with lithium showed a significant reduction in both SOD/CAT ratio and TBARS levels. These results suggest that initial manic episodes are associated with both increased oxidative stress parameters and activated antioxidant defenses, which may be related to dysfunctions on energy metabolism and neuroplasticity pathways. Antioxidant effects using lithium in mania were shown, and further studies are necessary to evaluate the potential role of these effects in the pathophysiology and therapeutics of BD. |
| Databáze: | OpenAIRE |
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