Planning, implementing, and running a multicentre preterm birth study with biobank resources in Brazil: The preterm samba study

Autor: Souza, Renato T, Cecatti, Jose G, Costa, Maria L, Mayrink, Jussara, Pacagnella, Rodolfo C, Jr, Passini Renato, Franchini, Kleber G, Feitosa, Francisco E, Calderon, Iracema M, Rocha Filho, Edilberto A, Leite, Debora F, Vettorazzi, Janete, Kenny, Louise C, Baker, Philip N, Parpinelli, Mary A, Fernandes, Karayna G, Guida, Jose P, Santana, Danielly, Barbosa, Ricardo M, Galvao, Rafael BF, Cassettari, Bianca F, Pfitscher, Lucia, de Feitosa, Daisy Lucena, Grp, Preterm SAMBA Study
Přispěvatelé: Universidade Estadual de Campinas (UNICAMP), Federal University of Ceará, Universidade Estadual Paulista (Unesp), Universidade Federal de Pernambuco (UFPE), Federal University of RS, University College Cork, University of Leicester, Gravida: National Centre for Growth and Development
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
BioMed Research International
BIOMED RESEARCH INTERNATIONAL
BioMed Research International, Vol 2019 (2019)
Popis: Made available in DSpace on 2019-10-06T16:15:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01 Background. Our aim was to describe the steps in planning, implementing, and running a multicentre cohort study of maternal and perinatal health using a high-quality biobank comprised of maternal serum, plasma, and hair samples collected from five sites in Brazil. The Preterm SAMBA study, conducted by the Brazilian Network for Studies on Reproductive and Perinatal Health, was an innovative approach used to identify women at higher risk for preterm birth. It is also of great importance in the study of other maternal and perinatal complications in the context of Brazil, which is a middle-income country. Methods. We described phases of planning, implementing, and running the Preterm SAMBA study, a multicentre Brazilian cohort study of low-risk nulliparous pregnant women, to validate a set of metabolite biomarkers for preterm birth identified in an external cohort. Procedures and strategies used to plan, implement, and maintain this multicentre preterm birth study are described in detail. Barriers and experience cited in the current narrative are not usually discussed in the scientific literature or published study protocols. Results. Several barriers and strategies were identified in different phases of the Preterm SAMBA study at different levels of the study framework (steering committee; coordinating and local centres). Strategies implemented and resources used in the study are a legacy of the Brazilian Network, aimed at training collaborators in such complex settings. Conclusion. The Brazilian Network for Studies on Reproductive and Perinatal Health has gained some experience in conducting a multicentre cohort study using a resourceful biobank which may be helpful to other research groups and maternal/perinatal health networks that plan on employing a similar approach to a similar background. Department of Obstetrics and Gynecology University of Campinas (UNICAMP) School of Medical Sciences LNBio-Brazilian National Laboratory of Biosciences University of Campinas (UNICAMP) School of Medical Sciences MEAC-Maternity School Federal University of Ceará Department of Obstetrics and Gynecology Botucatu Medical School Sao Paulo State University-Unesp Department of Maternal and Child Health Maternity of the Clinics Hospital Federal University of Pernambuco Department of Obstetrics and Gynecology Maternity of the Clinics Hospital Federal University of RS Irish Centre for Fetal and Neonatal Translational Research (INFANT) Department of Obstetrics and Gynaecology University College Cork College of Medicine Biological Sciences and Psychology University of Leicester Gravida: National Centre for Growth and Development Department of Obstetrics and Gynecology Botucatu Medical School Sao Paulo State University-Unesp
Databáze: OpenAIRE
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