The effect of diclofenac (Voltarol) and pethidine on ureteric peristalsis and the isotope renogram
| Autor: | H. J. Testa, Steven R. Payne, Jenny R. Prince, Martin J. R. Lancashire, Marge R. Rose, M. C. Prescott, Richard J. Brough |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Diclofenac Meperidine Analgesic Ureter Reference Values Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Peristalsis medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal Ureteric peristalsis Radioisotope renography General Medicine Blood flow Analgesics Opioid Radiography Pethidine stomatognathic diseases medicine.anatomical_structure Anesthesia business Radioisotope Renography medicine.drug |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 25:1520-1523 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s002590050330 |
| Popis: | Diclofenac (a non-steroidal anti-inflammatory drug) and pethidine (a synthetic opiate) are the two analgesics most commonly used to relieve the pain of ureteric colic. Fast frame renography is a non-invasive means of imaging ureteric peristalsis and renal drainage. The aim of this study was to determine the effects of each of these drugs on the drainage pattern of the upper tracts. Twelve normal male volunteers were studied. All underwent a standard fast frame renogram using 75 MBq of technetium-99m-mercaptoacetyltriglycine, and were then administered either 100 mg pethidine or 75 mg diclofenac by intramuscular injection. Fast frame renography was then repeated. Peristalsis was determined from the condensed image of each ureter and the renogram curves were analysed to obtain standard parameters and deconvolution analysis. Diclofenac caused a profound disruption to both ureteric peristalsis and the renogram curve. This effect was not seen after the administration of pethidine. Deconvolution analysis suggests the effects of diclofenac are mediated via a direct effect on drainage rather than by any alteration of blood flow to the kidney. This study suggests that pethidine is the analgesic of choice prior to renography and that inferences about alterations of drainage in the presence of diclofenac should be interpreted with care. |
| Databáze: | OpenAIRE |
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