Some Immunohormonal Changes in Experimentally Pregnant Toxemic Goats
| Autor: | Seham Youssef, Abd Elghany Hefnawy, Saad Shousha |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
endocrine system Article Subject medicine.medical_treatment education Blood sugar behavioral disciplines and activities Immune system Internal medicine mental disorders Ketogenesis Medicine Hydrocortisone Pregnancy lcsh:Veterinary medicine General Veterinary business.industry Insulin Thyroid medicine.disease Endocrinology medicine.anatomical_structure lcsh:SF600-1100 business psychological phenomena and processes medicine.drug Hormone Research Article |
| Zdroj: | Veterinary Medicine International, Vol 2010 (2010) Veterinary Medicine International |
| ISSN: | 2042-0048 |
| Popis: | Pregnancy toxemia was induced in nine pregnant goat does with twins by the stress of fasting with access to water in late pregnancy to investigate the effect of pregnancy toxemia on immunoglobulins (IgA, IgM, and IgG), cortisol, insulin, thyroid, and growth hormones and their correlations with the plasma levels of glucose andβ-Hydroxybutyrate. Plasma samples were collected at 0, 12, 24, 36, 48, and 72 hours after induction of pregnancy toxemia. The result revealed that experimental animals developed neurological findings with convulsions and acetone odor from the mouth with recumbency after 72 hours. Laboratory findings showed a significant increase inβ-Hydroxybutyrate, cortisol, and insulin while there were significant decreases in glucose, thyroid, and immunoglobulins (IgA, IgM, and IgG). Plasma glucose concentrations had significant negative correlations withβ-hydroxybutyrate, cortisol, and insulin while the correlations were significantly positive with immunoglobulins and thyroid hormone. Plasmaβ-hydroxybutyrate concentration was significantly positively correlated with cortisol and negatively correlated with immunoglobulins, insulin, and thyroid hormone. From this study we can conclude that pregnancy toxemia might affect humoral immune responses as well as insulin, cortisol, and thyroid hormones. Moreover, insulin might have a compensatory role to increase suppressive effect on ketogenesis in experimentally pregnant toxemic goats. |
| Databáze: | OpenAIRE |
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