Polarization-sensitive optical coherence tomography for imaging human atherosclerosis
| Autor: | Huan Jang Huang, Shoei-Shen Wang, Wen Chuan Kuo, Jeou-Jong Shyu, Chien Chou, Nai-Kuan Chou, Chih Ming Lai |
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| Rok vydání: | 2007 |
| Předmět: |
Materials science
genetic structures Materials Science (miscellaneous) Coronary Artery Disease In Vitro Techniques Sensitivity and Specificity Industrial and Manufacturing Engineering Optics Optical coherence tomography medicine Humans Business and International Management Aorta medicine.diagnostic_test business.industry Ultrasound Fibrous cap Reproducibility of Results Magnetic resonance imaging Equipment Design Image Enhancement eye diseases Equipment Failure Analysis Light intensity Refractometry Polarization sensitive medicine.anatomical_structure sense organs Tomography business Ex vivo Tomography Optical Coherence |
| Zdroj: | Applied optics. 46(13) |
| ISSN: | 1559-128X |
| Popis: | Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT with image contrast enhancement, which is based on its ability to detect phase retardation and the fast-axis angle. Both PS-OCT images and histopathology have demonstrated similar features that allowed differentiation of atherosclerotic structures (i.e., plaques) from normal tissue. Moreover, the picrosirius polarization method was used to confirm PS-OCT assessment of collagen in the fibrous cap of atherosclerotic plaques, and high-frequency (40 MHz) ultrasound images were used to identify calcium in the vessel wall. Our preliminary ex vivo investigation of human aortic specimens indicated that PS-OCT might help to identify atherosclerotic lesions. |
| Databáze: | OpenAIRE |
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