Kidney injury biomarkers after cardiac angiography in children with congenital heart disease

Autor: Masashi Nishida, Kazuyuki Ikeda, Shingo Kubo, Hajime Hosoi, Yuma Morishita, Toshiyuki Itoi, Kosuke Nishikawa
Rok vydání: 2019
Předmět:
Male
Heart disease
medicine.medical_treatment
Contrast Media
030204 cardiovascular system & hematology
urologic and male genital diseases
Coronary Angiography
Kidney
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Child
Cardiac catheterization
biology
medicine.diagnostic_test
Acute kidney injury
Age Factors
General Medicine
Acute Kidney Injury
Up-Regulation
Female
Cardiology and Cardiovascular Medicine
Heart Defects
Congenital
medicine.medical_specialty
Adolescent
Urinary system
Urology
Renal function
Urinalysis
Fatty Acid-Binding Proteins
Risk Assessment
03 medical and health sciences
Young Adult
Predictive Value of Tests
030225 pediatrics
Acetylglucosaminidase
medicine
Albuminuria
Humans
Radiology
Nuclear Medicine and imaging
Creatinine
urogenital system
business.industry
medicine.disease
chemistry
Cystatin C
Pediatrics
Perinatology and Child Health
Angiography
biology.protein
Surgery
business
beta 2-Microglobulin
Biomarkers
Zdroj: Congenital heart diseaseReferences. 14(6)
ISSN: 1747-0803
Popis: Objective This study aims to investigate the changes in renal function and levels of urinary biomarkers before and after cardiac angiography in children with congenital heart disease (CHD). Setting Children with CHD are at a risk for kidney injury during contrast exposure in cardiac angiography. Outcome measures We measured urinary protein, albumin, N-acetyl-β-D-glucosaminidase (NAG), β2-microglobulin (BMG), and liver-type fatty acid-binding protein (L-FABP) levels, as well as serum creatinine and cystatin C levels, before and after cardiac angiography in 33 children with CHD. Results No significant decrease was noted in either the creatinine-based or cystatin C-based estimated glomerular filtration rate at 24 hours after angiography compared with that before angiography. Urinary protein, NAG, BMG, and L-FABP levels were significantly increased at 24 hours after angiography, all of which returned to baseline levels at more than 7 days after angiography. An increase in urinary level of protein, albumin, NAG, or BMG was mostly associated with increased urinary L-FABP level. An increase in both urinary BMG and L-FABP, but not that in urinary L-FABP alone, was associated with increased levels of urinary protein and NAG, as well as the greater dose of contrast media. Conclusions Transient increases of kidney injury biomarkers following cardiac angiography are not necessarily associated with the impairment of renal function in a short time period; however, the increase in urinary protein, albumin, NAG, or BMG level may indicate greater stresses to the kidneys than the increase in urinary L-FABP alone in children with CHD.
Databáze: OpenAIRE
Externí odkaz: