Advances in Nanomaterials for Brain Microscopy
| Autor: | Markita P. Landry, Ian R. McFarlane, Linda Chio, Gabriel Dorlhiac, Jackson Travis Del Bonis-O'Donnell |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Computer science imaging Nanotechnology 02 engineering and technology Brain tissue 021001 nanoscience & nanotechnology Condensed Matter Physics Atomic and Molecular Physics and Optics Article Nanomaterials neuroscience 03 medical and health sciences 030104 developmental biology Neurochemical Optical imaging Neuroimaging Microscopy Microscopic imaging microscopy General Materials Science Electrical and Electronic Engineering Nanoscience & Nanotechnology 0210 nano-technology nanomaterials |
| Zdroj: | Nano research, vol 11, iss 10 Del Bonis-O’Donnell, JT; Chio, L; Dorlhiac, GF; McFarlane, IR; & Landry, MP. (2018). Advances in nanomaterials for brain microscopy. Nano Research, 11(10), 5144-5172. doi: 10.1007/s12274-018-2145-2. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/9546k727 |
| DOI: | 10.1007/s12274-018-2145-2. |
| Popis: | © 2018, Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature. Microscopic imaging of the brain continues to reveal details of its structure, connectivity, and function. To further improve our understanding of the emergent properties and functions of neural circuits, we need to directly visualize the relationship between brain structure, neuron activity, and neurochemistry. Advances in the chemical and optical properties of nanomaterials, and developments in deep-tissue microscopy, may help to overcome the current challenges of in-vivo brain imaging, particularly when imaging the brain through optically-dense brain tissue, skull, and scalp. Developments in nanomaterials may enable the implementation of tunable chemical functionality for neurochemical targeting and sensing, and fluorescence stability for long-term imaging. In this review, we summarize the current methods used for brain microscopy and describe the diverse classes of nanomaterials recently offered as contrast agents and functional probes for microscopic optical imaging of the brain. |
| Databáze: | OpenAIRE |
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