Clonal Differences among Erythromycin-ResistantStreptococcus pyogenesin Spain
| Autor: | Marimón Jm, B. Orden, Milagrosa Montes, de Pablos M, Emilio Pérez-Trallero |
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| Rok vydání: | 1999 |
| Předmět: |
Microbiology (medical)
Serotype Streptococcus pyogenes Epidemiology lcsh:Medicine Erythromycin Biology medicine.disease_cause lcsh:Infectious and parasitic diseases Microbiology Genotype medicine Pulsed-field gel electrophoresis lcsh:RC109-216 Genotyping lcsh:R Drug Resistance Microbial Phenotype Anti-Bacterial Agents Bacterial Typing Techniques Electrophoresis Gel Pulsed-Field Infectious Diseases Spain Efflux Research Article medicine.drug |
| Zdroj: | Emerging Infectious Diseases, Vol 5, Iss 2, Pp 235-240 (1999) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| DOI: | 10.3201/eid0502.990207 |
| Popis: | The aim of this study was to determine whether the high levels of erythromycin resistance in Streptococcus pyogenes found in Spain are due to the introduction and spread of one or more clones. Phenotypic and genotypic techniques were used to characterize all erythromycin-resistant S. pyogenes (ErR) isolated in Gipuzkoa, Spain, in the last 10 years and 128 ErR isolated in Vitoria and Madrid during 1996. Of 437 ErR, 97% had the M phenotype; all 283 of the strains studied had the mefA determinant of resistance. After biotyping, T serotyping, emm typing, and genotyping, four major clones were detected. Clones B (biotype I, type T4, emm4, pulsed-field gel electrophoresis [PFGE] II) and D (biotype V, type T8.25, emm75, PFGE IV) comprised 78.8% of all ErR. The resistance of S. pyogenes to erythromycin was mainly due to an efflux mechanism of resistance (M phenotype); few clones were responsible for it. |
| Databáze: | OpenAIRE |
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