Liver Resection for Hepatic Metastases from Soft Tissue Sarcoma: A Nationwide Study
| Autor: | Iris D. Nagtegaal, Frederike A B Grimme, Koert P. de Jong, Cornelis Verhoef, Richard van Hillegersberg, M F J Seesing, Johannes H. W. de Wilt, Frits van Coevorden |
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| Přispěvatelé: | Surgery, Groningen Institute for Organ Transplantation (GIOT), Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Rok vydání: | 2019 |
| Předmět: |
Leiomyosarcoma
Male Neoplasm Residual Colorectal cancer Soft Tissue Neoplasms Kaplan-Meier Estimate DISEASE COLORECTAL-CANCER Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] Postoperative Complications 0302 clinical medicine PROGNOSTIC-FACTORS Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] Liver metastasis Netherlands Aged 80 and over Liver resection Soft tissue sarcoma Liver Neoplasms Gastroenterology Sarcoma Middle Aged Progression-Free Survival SINGLE-CENTER EXPERIENCE Survival Rate medicine.anatomical_structure 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Adult medicine.medical_specialty Resection 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center medicine MANAGEMENT Hepatectomy Humans Survival analysis Aged Retrospective Studies R0 resection Original Paper business.industry medicine.disease Hepatic resection Surgery Feasibility Studies Abdomen business |
| Zdroj: | Digestive Surgery, 36, 6, pp. 479-486 Digestive Surgery, 36, 479-486 Digestive Surgery, 36(6), 479-486. Karger Digestive Surgery, 36(6), 479-486. KARGER Digestive Surgery, 36(6), 479. S. Karger AG |
| ISSN: | 0253-4886 |
| Popis: | Background: This study aims to evaluate the feasibility and safety of resection of sarcoma liver metastases, and to identify possible prognostic factors for long-term survival. Methods: All patients who underwent resection of liver metastases of sarcoma in the Netherlands from 1998 to 2014 were included. Study data was retrospectively collected from patient files. Survival rates were calculated using Kaplan-Meier survival analysis. Results: Some 38 patients treated in 16 hospitals were included (15 male, 23 female). The median age was 57 years (37–80 years). The most common histological subtype was leiomyosarcoma (63%). The predominant site of primary tumour was the abdomen (59%). R0 resection was achieved in 16 patients. Mortality was 3 and 16% of included patients had 1 or more complications. The median follow-up period was 18 months (range 1–161). After liver resection, 1-, 3-, and 5-year survival were 88, 54, and 42% respectively. Median overall survival was 46 months (1–161 months). One- and three-year progression-free survival (PFS) after liver resection were 54 and 19% respectively. Median PFS was 16 months (1–61 months). Conclusions: Liver surgery for sarcoma metastases is safe and leads to a relatively good survival. The choice for surgical treatment should always be discussed in a multidisciplinary sarcoma and liver team. |
| Databáze: | OpenAIRE |
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