Predictive factors of progression to severe COVID-19
| Autor: | Si-Kuan Ye, Vijay Harypursat, Yuan-Yuan Qin, Yan-Qiu Lu, Lu Zhang, Yaokai Chen, Hong-Lan Liu, Huan Li, Yan Wan, Xiaofeng Yan, Yihong Zhou |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
2019-20 coronavirus outbreak
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus macromolecular substances 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Retrospective analysis In patient 030212 general & internal medicine predictive biology business.industry musculoskeletal neural and ocular physiology Disease progression Hazard ratio General Medicine sars-cov-2 nervous system covid-19 biology.protein Medicine Creatine kinase progression business Research Article |
| Zdroj: | Open Medicine, Vol 15, Iss 1, Pp 805-814 (2020) Open Medicine |
| ISSN: | 2391-5463 |
| Popis: | Aim Early diagnosis and treatment are crucial for the survival of severe Coronavirus Disease 2019 (COVID-19) patients, but data with regard to risk factors for disease progression from milder COVID-19 to severe COVID-19 remain scarce. Methods We conducted a retrospective analysis on 116 patients. Results Three factors were observed to be independently associated with progression to severe COVID-19 during 14 days after admission: (a) age 65 years or older (hazard ratio [HR] = 8.456; 95% CI: 2.706–26.426); (b) creatine kinase (CK) ≥ 180 U/L (HR = 3.667; 95% CI: 1.253–10.733); and (c) CD4+ T-cell counts Conclusions Age ≥ 65 years, CK ≥ 180 U/L, and CD4+ T-cell counts |
| Databáze: | OpenAIRE |
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