Risk-benefit value of upper extremity function by an implanted electrical stimulation device targeting chronic cervical spinal cord injury
| Autor: | Megan Moynahan, Anne M. Bryden, Kim D. Anderson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 030506 rehabilitation medicine.medical_specialty Neuroprosthetics Adolescent Electric Stimulation Therapy Dermatology Quadriplegia Risk Assessment Article Likert scale Upper Extremity 03 medical and health sciences Young Adult 0302 clinical medicine Physical medicine and rehabilitation Intervention (counseling) Surveys and Questionnaires Medicine Humans Adverse effect Tetraplegia Spinal Cord Injuries Event (probability theory) Aged Aged 80 and over Relative value business.industry Cervical Cord Patient Preference Middle Aged medicine.disease Electrodes Implanted Cross-Sectional Studies Neurology Female Outcomes research 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Spinal Cord Ser Cases |
| Popis: | Study design A cross-sectional stated-preference survey using direct-assessment questions. Objective To determine the relative value placed on different outcomes to be used in a pivotal trial for the upper extremity configuration of the Networked Neuroprosthesis (NNP) as well as the tolerance of the expected adverse event profile. Setting Academic medical center in the United States. Methods Distribution of an online survey to adults living with tetraplegia; extent of agreement with each question/statement was obtaining using a 1-7 Likert scale. Results There were 8 statements about potential benefits in arm/hand function; for all statements, more than 70% of participants rated the functions as "1-very important" to regain. There were variable degrees of concern related to risks that could occur during the 30-day post-surgical period and increasing degrees of concern related to risks that could occur in the first 5 years, potentially due to the device, based on the increasing degree of invasiveness of the intervention required to address the event. When analysing the results based on all degrees of interest, more than 64% of responders were interested in getting the NNP with a success rate threshold as low as 50% regardless of time post-injury. Chi-squared analyses revealed some associations between responses and sex, injury level, and injury duration; however, none of these were statistically significant upon post-hoc analysis. Conclusion Data here indicate that people with tetraplegia are highly interested in a range of arm/hand functions and are tolerant of expected risks that may be associated with implanted neuroprosthetics. Sponsorship The Institute for Functional Restoration funded this project through a sub-contract to K.D. Anderson from a larger Special Projects Award (grant number FP0020773) from the Craig H. Neilsen Foundation. |
| Databáze: | OpenAIRE |
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