DNMT3A -448AG polymorphism and cancer risk: a meta-analysis
| Autor: | Shuqiu Chen, Kai Lu, Tao Tao, Bin Xu, Liang Jiang, Ming Chen, Chunhui Liu, Lei Zhang, Xiaowen Zhang, Dachuang Liu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty Methyltransferase Genotype Colorectal cancer Protective factor medicine.disease_cause Polymorphism Single Nucleotide Linkage Disequilibrium DNA Methyltransferase 3A Gene Frequency Risk Factors Internal medicine Neoplasms Genetics medicine Odds Ratio Humans Genetic Predisposition to Disease DNA (Cytosine-5-)-Methyltransferases Molecular Biology business.industry Public health General Medicine Odds ratio medicine.disease Confidence interval Meta-analysis embryonic structures Carcinogenesis business Colorectal Neoplasms |
| Zdroj: | Genetics and molecular research : GMR. 14(2) |
| ISSN: | 1676-5680 |
| Popis: | Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies have been conflicting. To clarify the role of DNMT3A polymorphisms in cancer, we conducted a meta-analysis of 2014 cases and 3089 control subjects. Odds ratios with 95% confidence intervals were estimated to evaluate the association between the DNMT3A -448A>G polymorphism and cancer risk. The results showed that DNMT3A may be a protective factor against all cancer types and colorectal cancer groups. Further studies should be conducted including different ethnicities and large population sizes to generate a comprehensive conclusion. |
| Databáze: | OpenAIRE |
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