H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease
| Autor: | Peter Radermacher, Christiane Waller, Nicole Denoix, Tamara Merz, Oscar McCook |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Heart disease
early life stress Cystathionine γ lyase hydrogen sulfide Early life stress Receptors Oxytocin Cystathionine beta-Synthase Communication link Disease 3-mercaptopyruvate sulphurtransferase Adverse Childhood Experiences cardiovascular disease oxytocin Medicine ddc:610 cystathionine-γ-lyase Hydrogen sulfide business.industry Cystathionine gamma-Lyase cystathionine β-synthase Cystathioninlyase Cystathionin-gamma-lyase General Medicine medicine.disease Oxytocin receptor Vagus nerve oxytocin receptor Cardiovascular Diseases Perspective Schwefelwasserstoff Kardiovaskuläre Krankheit business DDC 610 / Medicine & health Neuroscience medicine.drug |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 3484, p 3484 (2021) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10163484 |
| Popis: | oday it is well established that early life stress leads to cardiovascular programming that manifests in cardiovascular disease, but the mechanisms by which this occurs, are not fully understood. This perspective review examines the relevant literature that implicates the dysregulation of the gasomediator hydrogen sulfide and the neuroendocrine oxytocin systems in heart disease and their putative mechanistic role in the early life stress developmental origins of cardiovascular disease. Furthermore, interesting hints towards the mutual interaction of the hydrogen sulfide and OT systems are identified, especially with regards to the connection between the central nervous and the cardiovascular system, which support the role of the vagus nerve as a communication link between the brain and the heart in stress-mediated cardiovascular disease. publishedVersion |
| Databáze: | OpenAIRE |
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