Pasteurisation induced changes in an antithrombin III concentrate
| Autor: | L. Winkelman, M.E. Haddon |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Hot Temperature
Antithrombin III Pasteurization Protein aggregation In Vitro Techniques Chromatography Affinity law.invention Blood product law medicine Humans cardiovascular diseases Chemistry Heparin Antithrombin Antithrombin Activity Hematology Citrate ion carbohydrates (lipids) Disinfection Molecular Weight Binding ability Biochemistry Chromatography Gel Immunoelectrophoresis Two-Dimensional circulatory and respiratory physiology medicine.drug |
| Zdroj: | Thrombosis research. 43(2) |
| ISSN: | 0049-3848 |
| Popis: | The changes that take place when a therapeutic antithrombin III (AT III) concentrate is heated in the presence of citrate ion have been assessed. There is some loss of heparin cofactor antithrombin activity and of heparin binding ability. Protein aggregates are also formed during heating. These aggregates are not AT III but impurities in the concentrate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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