A simple saccadic reading test to assess ocular motor function in cerebellar ataxia

Autor: Angela Oh, Yaping Joyce Liao, Naz Jehangir, Mohammad Ali Shariati, Thomas N. Hwang, Tiffany A Chen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Cerebellum
Eye Movements
Physiology
Visual System
Vision
Sensory Physiology
Visual Acuity
lcsh:Medicine
Social Sciences
Neurological disorder
Audiology
0302 clinical medicine
Medicine and Health Sciences
Psychology
Attention
lcsh:Science
Multidisciplinary
Movement Disorders
Cognitive Neurology
Neurodegenerative Diseases
Middle Aged
Sensory Systems
Semantics
medicine.anatomical_structure
Neurology
Pattern Recognition
Visual
Saccade
Sensory Perception
Female
medicine.symptom
Research Article
medicine.medical_specialty
Cerebellar Ataxia
Cognitive Neuroscience
Fixation
Ocular
03 medical and health sciences
Neuropsychology
medicine
Humans
Neuropsychological Testing
Aged
Cerebellar ataxia
business.industry
lcsh:R
Cognitive Psychology
Eye movement
Biology and Life Sciences
Linguistics
medicine.disease
Gaze
Saccadic masking
Reading
Fixation (visual)
030221 ophthalmology & optometry
Cognitive Science
lcsh:Q
Ataxia
business
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0203924 (2018)
ISSN: 1932-6203
Popis: Cerebellar ataxia is a neurological disorder due to dysfunction of the cerebellum that affects coordination of fine movement, gait, and balance. Although ataxic patients commonly exhibit abnormal eye movement and have difficulties with saccadic reading, quantification of ocular motor abilities during reading in the clinical setting is rarely done. In this study, we assess visual performance with simple reading tests that can be used in the clinical setting and performed video infrared oculography in 11 patients with hereditary or acquired cerebellar ataxia and 11 age-matched controls. We found that compared with controls, ataxic patients read significantly slower on regularly and irregularly spaced 120 single-digit number reading tasks (read aloud) (p = 0.02 for both) but not on a word reading task (read silently), although there was large variability on the word reading task. Among the 3 reading tasks, the regularly spaced number reading task had the greatest difference (44%) between ataxic patients and controls. Analysis of oculography revealed that ataxic patients had slower reading speeds on the regularly spaced number reading task because of significantly higher saccade and fixation counts, impairment of small amplitude progressive saccades as well as large amplitude, line-changing saccades, greater fixation dispersion, and irregularity of scan paths and staircase gaze patterns. Our findings show that infrared oculography remains the gold standard in assessment of ocular motor difficulties during reading in ataxic patients. In the absence of this capability in the clinical setting, a simple 120 regularly spaced single-digit saccadic number reading test, which most patients can perform in less than 2 minutes, can be a possible biomarker for ocular motor abilities necessary for reading.
Databáze: OpenAIRE
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