A simple saccadic reading test to assess ocular motor function in cerebellar ataxia
Autor: | Angela Oh, Yaping Joyce Liao, Naz Jehangir, Mohammad Ali Shariati, Thomas N. Hwang, Tiffany A Chen |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Male
Cerebellum Eye Movements Physiology Visual System Vision Sensory Physiology Visual Acuity lcsh:Medicine Social Sciences Neurological disorder Audiology 0302 clinical medicine Medicine and Health Sciences Psychology Attention lcsh:Science Multidisciplinary Movement Disorders Cognitive Neurology Neurodegenerative Diseases Middle Aged Sensory Systems Semantics medicine.anatomical_structure Neurology Pattern Recognition Visual Saccade Sensory Perception Female medicine.symptom Research Article medicine.medical_specialty Cerebellar Ataxia Cognitive Neuroscience Fixation Ocular 03 medical and health sciences Neuropsychology medicine Humans Neuropsychological Testing Aged Cerebellar ataxia business.industry lcsh:R Cognitive Psychology Eye movement Biology and Life Sciences Linguistics medicine.disease Gaze Saccadic masking Reading Fixation (visual) 030221 ophthalmology & optometry Cognitive Science lcsh:Q Ataxia business 030217 neurology & neurosurgery Neuroscience |
Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 11, p e0203924 (2018) |
ISSN: | 1932-6203 |
Popis: | Cerebellar ataxia is a neurological disorder due to dysfunction of the cerebellum that affects coordination of fine movement, gait, and balance. Although ataxic patients commonly exhibit abnormal eye movement and have difficulties with saccadic reading, quantification of ocular motor abilities during reading in the clinical setting is rarely done. In this study, we assess visual performance with simple reading tests that can be used in the clinical setting and performed video infrared oculography in 11 patients with hereditary or acquired cerebellar ataxia and 11 age-matched controls. We found that compared with controls, ataxic patients read significantly slower on regularly and irregularly spaced 120 single-digit number reading tasks (read aloud) (p = 0.02 for both) but not on a word reading task (read silently), although there was large variability on the word reading task. Among the 3 reading tasks, the regularly spaced number reading task had the greatest difference (44%) between ataxic patients and controls. Analysis of oculography revealed that ataxic patients had slower reading speeds on the regularly spaced number reading task because of significantly higher saccade and fixation counts, impairment of small amplitude progressive saccades as well as large amplitude, line-changing saccades, greater fixation dispersion, and irregularity of scan paths and staircase gaze patterns. Our findings show that infrared oculography remains the gold standard in assessment of ocular motor difficulties during reading in ataxic patients. In the absence of this capability in the clinical setting, a simple 120 regularly spaced single-digit saccadic number reading test, which most patients can perform in less than 2 minutes, can be a possible biomarker for ocular motor abilities necessary for reading. |
Databáze: | OpenAIRE |
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