Genome‐wide association study for plasma very low‐density lipoprotein concentration in chicken

Autor:	Peng Luan, Jia-Qiang Yu, Zhiping Cao, Hui Zhang, Yumao Li, Lin-Yong Shen, Zi-Chun Xu, Xinyang Zhang
Rok vydání:	2019
Předmět:	medicine.medical_specialty Very low-density lipoprotein Single-nucleotide polymorphism Genome-wide association study Lipoproteins VLDL Biology Polymorphism Single Nucleotide Gene Frequency Food Animals Internal medicine Mixed linear model Blood plasma medicine Animals Gene Allele frequency Bird Diseases nutritional and metabolic diseases General Medicine Overweight Endocrinology lipids (amino acids peptides and proteins) Animal Science and Zoology Chickens Genome-Wide Association Study Lipoprotein
Zdroj:	Journal of Animal Breeding and Genetics. 136:351-361
ISSN:	1439-0388 0931-2668
DOI:	10.1111/jbg.12397
Popis:	The plasma very low-density lipoprotein (VLDL) concentration is an effective blood biochemical indicator that could be used to select lean chicken lines. In the current study, we used Genome-wide association study (GWAS) method to detect SNPs with significant effects on plasma VLDL concentration. As a result, 38 SNPs significantly associated with plasma VLDL concentration were identified using at least one of the three mixed linear model (MLM) packages, including GRAMMAR, EMMAX and GEMMA. Nearly, all these SNPs with significant effects on plasma VLDL concentration (except Gga_rs16160897) have significantly different allele frequencies between lean and fat lines. The 1-Mb regions surrounding these 38 SNPs were extracted, and twelve important regions were obtained after combining the overlaps. A total of 122 genes in these twelve important regions were detected. Among these genes, LRRK2, ABCD2, TLR4, E2F1, SUGP1, NCAN, KLF2 and RAB8A were identified as important genes for plasma VLDL concentration based on their basic functions. The results of this study may supply useful information to select lean chicken lines.
Databáze:	OpenAIRE
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