Soluble CD163 Predicts Incident Chronic Lung, Kidney and Liver Disease in HIV Infection
| Autor: | Susanne D. Poulsen, Ditte Marie Kirkegaard-Klitbo, Gitte Kronborg, Søren K. Moestrup, Thomas Benfield, Niels Mejer, Holger Jon Møller, Troels Bygum Knudsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Lung Diseases
0301 basic medicine Male Macrophage Kidney Diseases/epidemiology HIV Infections Disease SCD163 Monocyte Gastroenterology Receptors Cell Surface/blood Liver disease 0302 clinical medicine Immunology and Allergy Medicine 030212 general & internal medicine Prospective Studies Prospective cohort study Liver Diseases Incidence Hazard ratio Kidney disease Middle Aged Infectious Diseases Chronic Disease/epidemiology Kidney Diseases Female Adult medicine.medical_specialty Liver Diseases/epidemiology Immunology Lung Diseases/epidemiology Antigens CD/blood Antigens Differentiation Myelomonocytic Receptors Cell Surface Enzyme-Linked Immunosorbent Assay HIV Infections/complications 03 medical and health sciences Antigens CD Internal medicine Diabetes mellitus Journal Article Humans Antigens Differentiation Myelomonocytic/blood business.industry Proportional hazards model medicine.disease Comorbidity 030104 developmental biology Lung disease Chronic Disease HIV-1 business |
| Zdroj: | Kirkegaard-Klitbo, D M, Mejer, N, Knudsen, T B, Møller, H J, Moestrup, S K, Poulsen, S D, Kronborg, G & Benfield, T L 2017, ' Soluble CD163 Predicts Incident Chronic Lung, Kidney and Liver Disease in HIV Infection ', AIDS, vol. 31, no. 7, pp. 981–988 . https://doi.org/10.1097/QAD.0000000000001432 Kirkegaard-Klitbo, D M, Mejer, N, Knudsen, T B, Møller, H J, Moestrup, S K, Poulsen, S D, Kronborg, G & Benfield, T 2017, ' Soluble CD163 predicts incident chronic lung, kidney and liver disease in HIV infection ', AIDS, vol. 31, no. 7, pp. 981-988 . https://doi.org/10.1097/QAD.0000000000001432 |
| Popis: | OBJECTIVE: To examine if monocyte and macrophage activity may be on the mechanistic pathway to non-AIDS comorbidity by investigating the associations between plasma-soluble CD163 (sCD163) and incident non-AIDS comorbidities in well treated HIV-infected individuals.DESIGN: Prospective single-center cohort study.METHODS: Plasma sCD163 was quantified by ELISA technique at study entry in 2004/2005, and non-AIDS comorbidity was identified by International Classification of Disease Tenth revision diagnosis codes and registry linkage in 2014/2015. Associations between sCD163 and incident comorbidity was examined using multivariable Cox proportional hazards models adjusted for pertinent covariates.RESULTS: In HIV-1-infected individuals (n = 799), the highest quartile of plasma sCD163 was associated with incident chronic lung disease [adjusted hazard ratio (aHR), 3.2; 95% confidence interval (CI): 1.34; 7.46] and incident chronic kidney disease (aHR, 10.94; 95% CI: 2.32; 51.35), when compared with lowest quartiles. Further, (every 1 mg) increase in plasma sCD163 was positively correlated with incident liver disease (aHR, 1.12; 95% CI: 1.05; 1.19). The sCD163 level was not associated with incident cancer, cardiovascular disease or diabetes mellitus.CONCLUSION: sCD163 was independently associated with incident chronic kidney disease, chronic lung disease and liver disease in treated HIV-1-infected individuals, suggesting that monocyte/macrophage activation may be involved in the pathogenesis of non-AIDS comorbidity and a potential target for therapeutic intervention. |
| Databáze: | OpenAIRE |
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