CD 19 and BAFF ‐R can signal to promote B ‐cell survival in the absence of Syk

Autor: Ella Levit-Zerdoun, Michael Reth, Elias Hobeika, Roberta Pelanda, Vasiliki Anastasopoulou, Ameera Alsadeq, Roland Pohlmeyer, Marc-Werner Dobenecker, Simon Altmeier
Rok vydání: 2015
Předmět:
Lipopolysaccharides
Cell Survival
Antigens
CD19
B-cell receptor
Receptors
Antigen
B-Cell
Syk
CD38
Antibodies
General Biochemistry
Genetics and Molecular Biology
CD19
Mice
Phosphatidylinositol 3-Kinases
Antigens
CD
hemic and lymphatic diseases
medicine
Animals
Syk Kinase
CD40 Antigens
BAFF receptor
B-cell activating factor
Molecular Biology
B cell
Mice
Knockout
B-Lymphocytes
Membrane Glycoproteins
General Immunology and Microbiology
biology
General Neuroscience
Intracellular Signaling Peptides and Proteins
breakpoint cluster region
hemic and immune systems
Articles
Protein-Tyrosine Kinases
ADP-ribosyl Cyclase 1
Cell biology
Have You Seen?
medicine.anatomical_structure
Oligodeoxyribonucleotides
Cancer research
biology.protein
Interleukin-4
B-Cell Activation Factor Receptor
Signal Transduction
Zdroj: The EMBO Journal. 34:925-939
ISSN: 1460-2075
0261-4189
DOI: 10.15252/embj.201489732
Popis: The development and function of B lymphocytes is regulated by numerous signaling pathways, some emanating from the B-cell antigen receptor (BCR). The spleen tyrosine kinase (Syk) plays a central role in the activation of the BCR, but less is known about its contribution to the survival and maintenance of mature B cells. We generated mice with an inducible and B-cell-specific deletion of the Syk gene and found that a considerable fraction of mature Syk-negative B cells can survive in the periphery for an extended time. Syk-negative B cells are defective in BCR, RP105 and CD38 signaling but still respond to an IL-4, anti-CD40, CpG or LPS stimulus. Our in vivo experiments show that Syk-deficient B cells require BAFF receptor and CD19/PI3K signaling for their long-term survival. These studies also shed a new light on the signals regulating the maintenance of the normal mature murine B-cell pool.
Databáze: OpenAIRE
Externí odkaz: