Evaluation of the effects of Human leukocyte INF-alpha on the immune response to the HBV vaccine in healthy unvaccinated individuals
| Autor: | Paola Chionne, Francesca Urbani, Elisabeth A. Haygreen, Enrica Montefiore, Maria Rapicetta, Maria Grimaldi, Maria Rosaria Capobianchi, Imerio Capone, Ernesto Palazzini, Elisabeth Taylor, Persephone Borrow, Paola Rizza, Maria Elena Tosti, A. Scuteri, Marzia Margotti, Pietro Andreone, Filippo Belardelli, Carmela Cursaro, Concetta Castilletti, Giuseppe Claudio Viscomi, Marina Selleri, David F. Tough, Angela Candido |
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| Přispěvatelé: | Rizza P, Capone I, Urbani F, Montefiore E, Rapicetta M, Chionne P, Candido A, Tosti ME, Grimaldi M, Palazzini E, Viscomi G, Cursaro C, Margotti M, Scuteri A, Andreone P, Taylor E, Haygreen EA, Tough DF, Borrow P, Selleri M, Castilletti C, Capobianchi M, Belardelli F. |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Adolescent Adjuvant Interferon Vaccine medicine.medical_treatment Enzyme-Linked Immunosorbent Assay CD8-Positive T-Lymphocytes medicine.disease_cause Peripheral blood mononuclear cell Interferon-gamma Immune system Adjuvants Immunologic Immunity medicine Humans Hepatitis B Vaccines Hepatitis B Antibodies Antigen-presenting cell Aged Hepatitis B virus General Veterinary General Immunology and Microbiology business.industry Public Health Environmental and Occupational Health Interferon-alpha Dendritic cell Middle Aged Flow Cytometry Virology Lymphocyte Subsets Infectious Diseases Cytokine Immunoglobulin G Immunology Leukocytes Mononuclear Molecular Medicine Female business |
| Popis: | HBV vaccine needs 3 injections over 6 months to induce immunity. Thus, the use of adjuvants capable of inducing earlier immune protection would be highly desirable. Most adjuvants may act by inducing cytokines, and among them, type I interferons (IFNs), deserve a special attention in view of the potent immunomostimulatory activity observed in mouse models and on dendritic cell functions. The aim of the present trial was to evaluate the effects of IFN-alpha administered as an adjuvant of HBV vaccine in healthy unvaccinated individuals. No significant enhancing effect on the antibody response was observed, in spite of an early and transient upregulation of costimulatory molecule expression on peripheral blood mononuclear cells, which may be suggestive of an IFN-mediated activation of antigen presenting cells. We conclude that, under the conditions used in this trial, natural IFN-alpha does not act as an adjuvant of the HBV vaccine in healthy unvaccinated individuals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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