Protection of kids against Cryptosporidium parvum infection after immunization of dams with CP15-DNA
| Autor: | Muriel Naciri, Serge Sagodira, Daniel Bout, Sophie Iochmann, Dominique Buzoni-Gatel |
|---|---|
| Přispěvatelé: | UMR INRA / Univ. Tours : Immunologie parasitaire, Institut National de la Recherche Agronomique (INRA)-Université Francois Rabelais [Tours], Station de Pathologie aviaire et parasitologie [Nouzilly] (PAP), Institut National de la Recherche Agronomique (INRA), ProdInra, Migration |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Protozoan Vaccines
animal diseases medicine.medical_treatment [SDV]Life Sciences [q-bio] Protozoan Proteins CHEVREAU Antibodies Protozoan Cryptosporidiosis Passive immunity Biology DNA vaccination 03 medical and health sciences Immune system Immunity Pregnancy medicine Vaccines DNA Animals ComputingMilieux_MISCELLANEOUS 030304 developmental biology Cryptosporidium parvum 0303 health sciences Goat Diseases General Veterinary General Immunology and Microbiology 030306 microbiology Colostrum Goats Public Health Environmental and Occupational Health DNA Protozoan biology.organism_classification Virology humanities 3. Good health Vaccination [SDV] Life Sciences [q-bio] Infectious Diseases Immunization Animals Newborn Molecular Medicine VACCINATION Female |
| Zdroj: | Vaccine Vaccine, Elsevier, 1999, 17 (19), pp.2346-2355 |
| ISSN: | 0264-410X |
| Popis: | In this study the effectiveness of a DNA vaccine to confer protection against cryptosporidiosis, an enteric infection of lifestock and humans, was evaluated. A vaccination protocol using a recombinant plasmid encoding the 15 kDa surface sporozoite protein of Cryptosporidium parvum was developed in adult pregnant goats. The present study reports that nasal immunization of pregnant goats with CP15-DNA led to a transfer of immunity to offspring conferring protection against C. parvum infection. Kids from CP15-DNA-vaccinated dams shed significantly fewer oocysts and over a shorter period than did kids from unvaccinated goats. The low level of parasite development in protected kids did not affect their growth whereas unprotected kids grew much slowly. There was still a significant difference in the weights of protected and unprotected kids after complete recovery. Anti-CP15 antibodies were present in serum and colostrum from vaccinated goats. Nevertheless, the precise immune mechanism of protection has still to be determined. This vaccine should reduce the economic losses due to cryptosporidiosis in ruminants, specially in small ruminants (calves, lambs, kids). It has also the potential to reduce environmental contamination by reducing oocyst shedding. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect