The pathophysiology of preeclampsia in view of the two-stage model
| Autor: | Zita Pánczél, Bálint Alasztics, Sándor Valent, Zoltán Kukor |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
HELLP Syndrome
medicine.medical_specialty HELLP syndrome Placenta Physiology Disease Preeclampsia Renin-Angiotensin System Pre-Eclampsia Pregnancy Internal medicine medicine Edema Humans Eclampsia Endothelial dysfunction Hemostasis Blood Volume Proteinuria business.industry General Medicine medicine.disease Oxidative Stress medicine.anatomical_structure Endocrinology Pregnancy Trimester Second embryonic structures Female Endothelium Vascular Nitric Oxide Synthase medicine.symptom business |
| Zdroj: | Orvosi Hetilap. 153:1167-1176 |
| ISSN: | 1788-6120 0030-6002 |
| DOI: | 10.1556/oh.2012.29415 |
| Popis: | Preeclampsia is a common and severe disease in pregnancy, a major cause of maternal and fetal morbidity and mortality. The main features of the disease are de novo hypertension after the 20th gestational week and proteinuria, and it is frequently accompanied by edema and other subjective symptoms. The origin of the disease is the placenta, but its sequelae affect multiple organ systems. According to the two-stage model of preeclampsia, the abnormal and hypoperfused placenta (stage 1) releases factors to the bloodstream, which are responsible for the maternal symptoms (stage 2). Oxidative stress, impaired function of nitric-oxide synthase, cellular and humoral immunological factors play an important role in the pathophysiology of the placenta. Endothelial dysfunction is the common denominator of the clinical symptoms. The theory explains the origins of hypertension, proteinuria, edema and other symptoms as well. Orv. Hetil., 2012, 153, 1167–1176. |
| Databáze: | OpenAIRE |
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