Diagnostic value of glypican-3, arginase-1 and hepatocyte paraffin antigen -1 in differentiating hepatocellular carcinoma from intrahepatic cholangiocarcinoma
| Autor: | Cong-Rong Wang, Chun-Mei Xie, Xiao Xu, Juan-Ping Yu, Jian Yang, Xuanyu Zhang, Yu Li, Xiang-Yang Shao, Weiwen Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty business.industry glypican-3 (GPC3) medicine.disease Gastroenterology Glypican 3 arginase-1 (Arg-1) digestive system diseases Arginase medicine.anatomical_structure Oncology Antigen Internal medicine Hepatocyte Hepatocellular carcinoma Medicine Immunohistochemistry biomarker Radiology Nuclear Medicine and imaging Original Article hepatocyte paraffin antigen 1 (HepPar-1) Hepatocellular carcinoma (HCC) business Intrahepatic Cholangiocarcinoma |
| Zdroj: | Translational Cancer Research |
| ISSN: | 2219-6803 2218-676X |
| Popis: | Background The aim of the present study was to investigate the diagnostic value of glypican-3 (GPC3), arginase-1 (Arg-1), and hepatocyte paraffin antigen 1 (HepPar-1) in differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC). Methods The expression of GPC3, HepPar-1 and Arg-1 were measured by immunohistochemistry in 47 cases of HCC, 29 cases of ICC and their paracancerous tissues. Results A high expression of GPC3, Arg-1 and HepPar-1 was observed in HCC tissues (68.09%, 76.60% and 78.72%, respectively; P>0.0125) while it was lower in ICC tissues (6.90%, 6.90% and 13.79%, respectively; P>0.0125). With regard to specificity, GPC3 performed better than Arg-1 and HepPar-1 (97.37% vs. 1.32% and 2.63%, respectively; P |
| Databáze: | OpenAIRE |
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