Polymorphisms in the vitamin D receptor gene and parathyroid hormone gene in the development and progression of diabetes mellitus and its chronic complications, diabetic nephropathy and non-diabetic renal disease
| Autor: | Anna Kotrbova-Kozak, Zelezníková, Marie Cerna, Vedralová M, Hana Zoubková, Ivan Rychlik |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty TaqI Genotype Parathyroid hormone Biology Calcitriol receptor Nephropathy Diabetic nephropathy chemistry.chemical_compound Gene Frequency Internal medicine Diabetes mellitus medicine Prevalence Humans Diabetic Nephropathies Genetic Predisposition to Disease Aged Czech Republic Aged 80 and over Polymorphism Genetic Haplotype General Medicine Middle Aged medicine.disease FokI Endocrinology Diabetes Mellitus Type 1 chemistry Diabetes Mellitus Type 2 Haplotypes Nephrology Parathyroid Hormone Case-Control Studies biology.protein Disease Progression Receptors Calcitriol Female Kidney Diseases Cardiology and Cardiovascular Medicine |
| Zdroj: | Kidneyblood pressure research. 36(1) |
| ISSN: | 1423-0143 |
| Popis: | Background: We chose to study polymorphisms of vitamin D receptor gene (VDR) and parathyroid hormone genes (PTH), whose protein products significantly affect calciumphosphate metabolism in kidneys and are implicated in the pathogenesis of diabetes, which may also involve kidney damage. Methods: Distribution of genotypes of four polymorphisms in VDR gene i.e TaqI (rs731236), BsmI (rs1544410) ApaI (rs7975232), FokI (rs2228570) and two polymorphisms of PTH gene, i.e. DraII (rs6256), BstBI (rs6264), were studied using PCRRFLP. Examined groups consisted of 147 patients with diabetes (DM), 47 patients with nondiabetic renal disease (NDRD), 132 patients with diabetic nephropathy (DN) and 118 healthy subjects. Conclusion: Comparison of DN group and healthy subjects identified statistically significant difference for the FokI polymorphism in VDR gene (PBstBI polymorphism in PTH gene (P=0,023). Differences in DraII polymorphism distribution in PTH gene were statistically significant in each group of patients compared to healthy subjects. In DN patients, the BBFFAATt combination of VDR gene was more frequent than in healthy subjects (P=0,046), and the BbFFAaTt variant was more frequent than in DM2 patients (P=0,018). The BBDD haplotype of PTH gene seems to be a predisposing factor for diabetes itself (P=0,019). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|