Retinoic acid and transforming growth factor β differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation
| Autor: | Bernard H. Davis, U R Rapp, N O Davidson |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Retinoic acid Receptors Cell Surface Tretinoin Retinoic acid receptor beta digestive system Biochemistry chemistry.chemical_compound Transforming Growth Factor beta Internal medicine medicine Animals Receptors Platelet-Derived Growth Factor Molecular Biology Cells Cultured Platelet-Derived Growth Factor biology Rats Inbred Strains DNA Cell Biology Transforming growth factor beta TGF beta receptor 2 Endoglin Actins Rats Cell biology Endocrinology Liver chemistry Transforming growth factor beta 3 biology.protein Cell Division Platelet-derived growth factor receptor Research Article medicine.drug |
| Zdroj: | Biochemical Journal. 278:43-47 |
| ISSN: | 1470-8728 0264-6021 |
| Popis: | Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor beta (TGF beta) both inhibit Ito-cell [3H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGF beta blocked PDGF-induced cell proliferation. TGF beta, but not retinoic acid, diminished PDGF-receptor and smooth-muscle alpha-actin abundance. |
| Databáze: | OpenAIRE |
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