Intravoxel water diffusion heterogeneity MR imaging of nasopharyngeal carcinoma using stretched exponential diffusion model
| Autor: | Pek-Lan Khong, Ka-On Lam, Victor Ho-Fun Lee, Queenie Chan, Henry Chun Kin Sze, Vincent Lai |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Sensitivity and Specificity Likelihood ratios in diagnostic testing Diffusion Body Water Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Diffusion (business) Stage (cooking) Grading (tumors) Aged Neoplasm Staging Aged 80 and over Nasopharyngeal Carcinoma medicine.diagnostic_test business.industry Carcinoma Nasopharyngeal Neoplasms Magnetic resonance imaging General Medicine Middle Aged medicine.disease Exponential function Diffusion Magnetic Resonance Imaging ROC Curve Nasopharyngeal carcinoma Female Radiology business Diffusion MRI |
| Zdroj: | European Radiology. 25:1708-1713 |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-014-3535-9 |
| Popis: | To determine the utility of stretched exponential diffusion model in characterisation of the water diffusion heterogeneity in different tumour stages of nasopharyngeal carcinoma (NPC). Fifty patients with newly diagnosed NPC were prospectively recruited. Diffusion-weighted MR imaging was performed using five b values (0–2,500 s/mm2). Respective stretched exponential parameters (DDC, distributed diffusion coefficient; and alpha (α), water heterogeneity) were calculated. Patients were stratified into low and high tumour stage groups based on the American Joint Committee on Cancer (AJCC) staging for determination of the predictive powers of DDC and α using t test and ROC curve analyses. The mean ± standard deviation values were DDC = 0.692 ± 0.199 (×10−3 mm2/s) for low stage group vs 0.794 ± 0.253 (×10−3 mm2/s) for high stage group; α = 0.792 ± 0.145 for low stage group vs 0.698 ± 0.155 for high stage group. α was significantly lower in the high stage group while DDC was negatively correlated. DDC and α were both reliable independent predictors (p |
| Databáze: | OpenAIRE |
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