Systematic Review and Meta-analysis of En Bloc Vertebrectomy Compared with Intralesional Resection for Giant Cell Tumors of the Mobile Spine
| Autor: | Weerasak Singhatanadgige, David B. Bumpass, Panya Luksanapruksa, Jacob M. Buchowski |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
recurrence Review Article 03 medical and health sciences 0302 clinical medicine en bloc vertebrectomy medicine postoperative complications Orthopedics and Sports Medicine 030212 general & internal medicine Giant Cell Tumors giant cell tumor business.industry Postoperative complication intralesional resection mobile spine Perioperative Sacrum Confidence interval Surgery meta-analysis Meta-analysis Relative risk Vertebrectomy Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Global Spine Journal |
| ISSN: | 2192-5682 |
| Popis: | Study Design Systematic review and meta-analysis. Objective To compare the recurrence and perioperative complication rate of en bloc vertebrectomy (EV) and intralesional resection (IR) in the giant cell tumor of the mobile spine (SGCT). Methods We systematically searched publications in the PubMed and Embase databases for reports of SGCTs, excluding the sacrum. Two reviewers independently assessed all publications. A meta-analysis was performed using local recurrence and postoperative complications as the primary outcomes of interest. Results There were four articles reporting recurrence and two articles reporting postoperative complications. All included articles were case series. In all, 91 patients were included; 49 were treated with IR and 42 were treated with EV. Local recurrence rates were 36.7 and 9.5% in the IR and EV groups, respectively. Rates of postoperative complications were 36.4% with IR and 11.1% with EV. Overall, patients treated with EV not only had a lower recurrence rate (relative risk [RR] 0.22; 95% confidence interval [CI] 0.09 to 0.52) but also had a lower postoperative complication rate (RR 0.34; 95% CI 0.07 to 1.52) compared with IR. Conclusions Based on the limited data obtained from systematic review, SGCT patients treated with EV had a lower recurrence rate and fewer postoperative complications than those treated with IR. |
| Databáze: | OpenAIRE |
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