Solid Pseudopapillary Neoplasms of the Pancreas: a 19-Year Multicenter Experience in China
| Autor: | Yian Du, Pengfei Yu, Zhiyuan Xu, Xiangdong Cheng, Zhengxiang Zhong, Xiaoguang Wang, Hongbao Xu, Conggang Hu, Wenjuan Yin, Litao Yang |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male China medicine.medical_specialty Adolescent medicine.medical_treatment Pancreaticoduodenectomy Young Adult Pancreatectomy medicine Hepatectomy Humans Survival rate Retrospective Studies business.industry General surgery Gastroenterology Retrospective cohort study Middle Aged Prognosis Pancreatic Neoplasms Survival Rate Ki-67 Antigen Treatment Outcome medicine.anatomical_structure Multicenter study Clinicopathological features Female Surgery Neoplasm Recurrence Local Pancreas business |
| Zdroj: | Journal of Gastrointestinal Surgery. 19:1433-1440 |
| ISSN: | 1873-4626 1091-255X |
| DOI: | 10.1007/s11605-015-2862-8 |
| Popis: | The aim of this study was to determine the clinicopathological features, surgical management, and prognosis of solid pseudopapillary neoplasms (SPNs) of the pancreas.This study conducted a retrospective analysis of 97 patients who underwent surgery for a pathologically confirmed SPN in five hospitals between January 1996 and December 2014.The 97 cases included 93 female and 4 male patients, and the average age was 31.2 years. The tumor was located in the body or tail (70.1%), the head (20.6%), and the neck (9.3%). All patients underwent surgical exploration, including distal pancreatectomy (63.9%), pancreaticoduodenectomy (20.6%) (partial portal vein or superior mesenteric vein resection and artificial vascular graft reconstruction performed in 4.1% of the patients), central pancreatectomy (10.3%), enucleation (5.2%), and liver resection (1.0%). 16.5% of the patients had malignant tumors. The positive rate of Ki-67 was 66.7% in patients diagnosed with a malignant neoplasm and was comparable to 8.4% of the patients diagnosed to have a benign neoplasm (p 0.001). After a median follow-up of 70.1 months, three patients had recurrence and one patient died of liver metastasis.SPN is a rare neoplasm with low malignant potential. Surgical resection is warranted even in the presence of local invasion or metastases as patients demonstrate excellent long-term survival. Positive immunoreactivity for Ki-67 may predict the malignant potential and poor outcome of SPNs. |
| Databáze: | OpenAIRE |
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