Extracellular matrix composition defines an ultra-high-risk group of neuroblastoma within the high-risk patient cohort
| Autor: | Ana P. Berbegall, Irene Tadeo, Victoria Castel, Rosa Noguera, Purificación García-Miguel, Samuel Navarro, Robert C. Callaghan, Sven Påhlman |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Risk Cancer Research Pathology medicine.medical_specialty blood vascularisation Colorectal cancer Kaplan-Meier Estimate Risk Assessment Collagen Type I Extracellular matrix 03 medical and health sciences Prostate cancer Neuroblastoma neuroblastoma 0302 clinical medicine medicine Humans Survival rate Molecular Diagnostics collagen type I fibres business.industry Brain Neoplasms ultra-high-risk neuroblastoma Infant elastic fibres medicine.disease Elastic Tissue Prognosis Survival Rate Reticulin 030104 developmental biology medicine.anatomical_structure Oncology glycosaminoglycans 030220 oncology & carcinogenesis Blood Vessels reticulin fibres Bone marrow Skin cancer Liver cancer business |
| Zdroj: | BRITISH JOURNAL OF CANCER r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe British Journal of Cancer Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| ISSN: | 0007-0920 |
| Popis: | Background: Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die. Methods: We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundles, elastic fibres and glycosaminoglycans in 102 high-risk neuroblastomas specimens. The Kaplan-Meier method was used to correlate the analysed elements with survival. Results: The organisation of blood vessels and reticulin fibres in neuroblastic tumours defined an ultra-high-risk patient subgroup with 5-year survival rate |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink