Systematic review and meta-analysis of cardiovascular risk in rheumatological disease: Symptomatic and non-symptomatic events in rheumatoid arthritis and systemic lupus erythematosus
| Autor: | Francesco Ciccia, Vincenzo Restivo, Rosario Luca Norrito, Stefania Candiloro, Serena Fasano, Mario Daidone, Giuseppa Minutolo, Antonino Tuttolomondo, Marco Cataldi, Francesca Caracci, Alessandra Casuccio |
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| Přispěvatelé: | Restivo, V, Candiloro, S, Daidone, M, Norrito, R, Cataldi, M, Minutolo, G, Caracci, F, Fasano, S, Ciccia, F, Casuccio, A, Tuttolomondo, A., Restivo V., Candiloro S., Daidone M., Norrito R., Cataldi M., Minutolo G., Caracci F., Fasano S., Ciccia F., Casuccio A., Tuttolomondo A. |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Immunology Disease Asymptomatic Arthritis Rheumatoid Risk Factors Internal medicine medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Prospective Studies Prospective cohort study Retrospective Studies Autoimmune disease business.industry Incidence (epidemiology) medicine.disease Cardiovascular Diseases Heart Disease Risk Factors Age Cardiovascular events Metaanalysis Rheumatoid arthritis Risk Systemic lupus erythematosus Meta-analysis Rheumatoid arthritis Inclusion and exclusion criteria medicine.symptom business |
| Zdroj: | Autoimmunity Reviews. 21:102925 |
| ISSN: | 1568-9972 |
| DOI: | 10.1016/j.autrev.2021.102925 |
| Popis: | Although each autoimmune disease is associated with specific tissue or organ damage, rheumatic diseases share a pro-inflammatory pattern that might increase cardiovascular risk. Retrospective and prospective studies on patients affected by systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) highlighted the concept of “accelerated atherosclerosis”. Therefore, the purpose of this systematic review and meta-analysis is the assessment of symptomatic or asymptomatic cardiovascular events among patients with rheumatic diseases as RA and SLE. The literature research obtained all manuscripts published in the English language between 2015 and 2019 for a total of 2355 manuscripts. After selection through inclusion and exclusion criteria, four articles examined cardiovascular risk in RA patients, 8 in SLE patients, and 2 in RA and SLE patients. Patients with SLE had a RR of 1.98 (95% CI: 1.18–3.31) of symptomatic cardiovascular events compared to the unexposed cohort. The meta-regression analysis showed that younger patient (age per year increase β = −0.12 95%CI: −0.20, −0.4), belonging to studies conducted in continent different from America (β = −0.89; −95% CI: 1.67, −0.10), after 2000 (β = 0.87; 95% CI: 0.09, 1.65) and with a higher quality score 0.80 (95% CI: 0.31, 1.29) had a higher risk of cardiovascular events. In patients with RA, the RR of cardiovascular events was 1.55 (95% CI: 1.18–2.02). These data are helpful to implement cardiovascular preventive strategies among people suffering from rheumatologic diseases to decrease the incidence of cardiovascular events. However, these implementation needs to build a higher network between rheumatologists and primary care healthcare workers to furnish the same information to patients and monitor their preventive practice compliance. |
| Databáze: | OpenAIRE |
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