Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli
| Autor: | Satoshi Yuzawa, Leonard Katz, Woncheol Kim, Jay D. Keasling |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Biological Products
Biomedical Engineering Heterologous Polyketide biosynthesis Bioengineering Protein engineering Biology biology.organism_classification medicine.disease_cause Protein Engineering Streptomyces law.invention Microbiology Metabolic engineering Polyketide Biochemistry law Polyketides medicine Recombinant DNA Escherichia coli Synthetic Biology Polyketide Synthases Biotechnology |
| Zdroj: | Current opinion in biotechnology. 23(5) |
| ISSN: | 1879-0429 |
| Popis: | Heterologous production of polyketide compounds, an important class of natural products with complex chemical structures, was first demonstrated with Streptomyces parvulus in 1984. Although Streptomyces strains are good first options for heterologous polyketide biosynthesis, their slow growth kinetics prompt other hosts to also be considered. Escherichia coli provides key elements of an ideal host in terms of the growth rate, culture conditions, and available recombinant DNA tools. Here we review the current status and potential for metabolic engineering of polyketides in E. coli. |
| Databáze: | OpenAIRE |
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