HBsAg Clearance in Patients with Long-Standing Chronic Active Hepatitis B and Hepatitis B Virus-Induced Liver Cirrhosis
| Autor: | Thomas Poralla, Michael Manns, T. H. Hütteroth, K. H. Meyer zum Büschenfelde, H. H. Dormeyer, G. Hess |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Liver Cirrhosis Male HBsAg medicine.medical_specialty Time Factors Cirrhosis Azathioprine medicine.disease_cause Gastroenterology Internal medicine medicine Humans Aspartate Aminotransferases Hepatitis B Antibodies Hepatitis Chronic Hepatitis B virus Hepatitis B Surface Antigens business.industry Hepatobiliary disease virus diseases Alanine Transaminase Middle Aged Hepatitis B medicine.disease digestive system diseases Carrier State Immunology Prednisolone Female Viral disease business medicine.drug |
| Zdroj: | Digestion. 33:53-60 |
| ISSN: | 1421-9867 0012-2823 |
| Popis: | During a period of 3 years we observed 5 patients with chronic active hepatitis B and 2 with hepatitis B virus-induced liver cirrhosis who cleared HBsAg from their sera after 2-14 years of HBsAg carriership. 4 of them developed anti-HBs. After HBsAg clearance there was no evidence of persisting inflammatory activity within their livers. 5 of the 7 patients had been treated for 1-39 months with prednisolone, sometimes in combination with azathioprine. This therapy, however, had been stopped more than 3 years before these patients terminated their HBsAg carriership. Our observations indicate that even after long-standing chronic active hepatitis B or hepatitis B virus-induced liver cirrhosis HBsAg may be eliminated in a considerable number of patients. |
| Databáze: | OpenAIRE |
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