Biochemical and cellular properties of insulin receptor signalling
Autor: | Domenico Accili, Timothy E. McGraw, Rebecca A. Haeusler |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Transcription Genetic medicine.medical_treatment Type 2 diabetes Bioinformatics Article 03 medical and health sciences Insulin resistance Diabetes mellitus medicine Animals Humans Insulin Receptor Molecular Biology biology Kinase business.industry Cell Biology medicine.disease IRS2 Receptor Insulin Insulin receptor 030104 developmental biology biology.protein business Signal Transduction |
Zdroj: | Nature reviews. Molecular cell biology. 19(1) |
ISSN: | 1471-0080 |
Popis: | The mechanism of insulin action is a central theme in biology and medicine. In addition to the rather rare condition of insulin deficiency caused by autoimmune destruction of pancreatic β-cells, genetic and acquired abnormalities of insulin action underlie the far more common conditions of type 2 diabetes, obesity and insulin resistance. The latter predisposes to diseases ranging from hypertension to Alzheimer disease and cancer. Hence, understanding the biochemical and cellular properties of insulin receptor signalling is arguably a priority in biomedical research. In the past decade, major progress has led to the delineation of mechanisms of glucose transport, lipid synthesis, storage and mobilization. In addition to direct effects of insulin on signalling kinases and metabolic enzymes, the discovery of mechanisms of insulin-regulated gene transcription has led to a reassessment of the general principles of insulin action. These advances will accelerate the discovery of new treatment modalities for diabetes. |
Databáze: | OpenAIRE |
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