Cytogenetic assessment of Iranian infertile men with undescended testis: A retrospective study
| Autor: | Anahita Mohseni Meybodi, Neda Sharifi, Parnaz Borjian Boroujeni, Faramarz Farrahi, Navid Almadani, Marjan Sabbaghian |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty media_common.quotation_subject Population 030232 urology & nephrology Fertility Iran cytogenetics male infertility Male infertility 03 medical and health sciences Klinefelter Syndrome 0302 clinical medicine Cryptorchidism medicine Humans education Infertility Male Retrospective Studies media_common Gynecology education.field_of_study 030219 obstetrics & reproductive medicine Genitourinary system business.industry Incidence (epidemiology) Iranian population Cytogenetics undescended testis Retrospective cohort study Middle Aged medicine.disease Cytogenetic Analysis Original Article Klinefelter syndrome business |
| Zdroj: | JBRA Assisted Reproduction |
| ISSN: | 1518-0557 |
| DOI: | 10.5935/1518-0557.20200006 |
| Popis: | Objective Undescended testis (UDT) is a urogenital disease that affects fertility. This study looked into the cytogenetic abnormalities of Iranian infertile patients with UDT. Methods Our study included 522 infertile patients with UDT (case group) and two control groups, one with 300 infertile men without UDT and another with 268 fertile men. Results Chromosomal abnormalities were found in 45 patients with UDT (8.62%). Seven of the alterations were considered as normal features. Klinefelter syndrome and mosaicism were the most common anomalies. Chromosomal abnormalities were found in 31 infertile men in the control group (10.33%), 13 of which deemed normal and 18 (6%) anomalous. Nine chromosomal abnormalities were found in the second control group with fertile men (3.35%), six deemed normal and three (1.11%) anomalous. Conclusion Despite the high rate of abnormalities in infertile controls (6%) and the higher rate seen in infertile individuals with UDT indicate a significant prevalence of chromosomal abnormalities in the Iranian population, particularly when the literature suggests that the normal rate of abnormal karyotypes should be within the 0.7-1% range in the general population. The incidence of abnormal karyotypes increased when infertile patients had additional conditions such as UDT. |
| Databáze: | OpenAIRE |
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