Effect of an Acute Dose of Ethanol on Lipid Peroxidation and on the Activity of Microsomal Glutathione S-Transferase in Rat Liver
| Autor: | Helmuth Sippel |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Lipid Peroxides medicine.medical_specialty Glutathione reductase Toxicology GPX4 Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Glutathione Transferase 030304 developmental biology Fomepizole Pharmacology 0303 health sciences Ethanol Lipid peroxide biology Rats Inbred Strains Glutathione Rats 3. Good health Endocrinology Glutathione S-transferase chemistry Biochemistry 030220 oncology & carcinogenesis Microsomes Liver Microsome biology.protein Pyrazoles |
| Zdroj: | Acta Pharmacologica et Toxicologica. 53:135-140 |
| ISSN: | 0001-6683 |
| DOI: | 10.1111/j.1600-0773.1983.tb01881.x |
| Popis: | Acute ethanol administration (1.5 g/kg) to fasted rats resulted in a small but significant increase in the content of conjugated dienes in the microsomal fraction of liver. Treatment with 4-methylpyrazole prior to ethanol ingestion was able to reduce the ethanol-induced lipid peroxide formation (measured as conjugated dienes). No depletion of glutathione occurred within the first 2 hrs following ethanol administration by which time lipid peroxide formation is well established. The ethanol-induced inhibition of N-ethylmaleimide-stimulated microsomal glutathione S-transferase activity correlates positively to the concentration of conjugated dienes in the microsomal fraction of liver. |
| Databáze: | OpenAIRE |
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