Measles Vaccination in Presence of Measles Antibody May Enhance Child Survival
| Autor: | Cesario Martins, Andreas Andersen, Christine Stabell Benn, Hilton Whittle, Peter Aaby, Ane Bærent Fisker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty maternal antibodies (matab) 030204 cardiovascular system & hematology Measles child mortality in Africa 03 medical and health sciences 0302 clinical medicine heterologous (non-specific) effects of vaccines 030225 pediatrics vaccine Medicine measles Seroconversion Beneficial effects Original Research Child survival business.industry Mortality rate lcsh:RJ1-570 lcsh:Pediatrics medicine.disease Vaccination Pediatrics Perinatology and Child Health business Measles antibody Lower mortality |
| Zdroj: | Frontiers in Pediatrics, Vol 8 (2020) Frontiers in Pediatrics Benn, C S, Martins, C L, Andersen, A, Fisker, A B, Whittle, H C & Aaby, P 2020, ' Measles Vaccination in Presence of Measles Antibody May Enhance Child Survival ', Frontiers in Pediatrics, vol. 8, 20 . https://doi.org/10.3389/fped.2020.00020 |
| ISSN: | 2296-2360 |
| DOI: | 10.3389/fped.2020.00020/full |
| Popis: | Background: In trials of early two-dose measles vaccination (MV), with the first dose being given before 9 months of age, vaccination in the presence of maternal antibody reduced mortality 2- to 3-fold compared with MV in the presence of no measles antibody. We tested this finding in two historical studies in which the children had received one dose of MV. Methods: We used data from a surveillance study of seroconversion after standard-titer MV (Schwarz strain) (Study 1) and a trial of early medium-titer MV (Edmonston-Zagreb strain) in which a pre-vaccination blood sample had been collected (Study 2). Both studies had control children, who were enrolled under similar conditions, but did not receive effective MV. Study 1 was a natural experiment where all children measles vaccinated during 1 month did not seroconvert and had therefore received an ineffective vaccine. In Study 2, the controls were randomized to an inactivated polio vaccine (IPV). We compared mortality for children with undetectable levels of measles antibody ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|